Determinants of maximally attained level of pulmonary function

Xiaobin Wang, Tjeert T. Mensinga, Jan P. Schouten, Bert Rijcken, Scott T. Weiss

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


This study investigated the determinants of sex-specific maximally attained levels of FEV1, VC, and the ratio of FEV1 to VC. Subjects were between the ages of 15 and 35 years (1,818 males and 1,732 females), participating in the Vlagtwedde/Vlaardingen study in The Netherlands. The subjects were followed (3-year intervals) with questionnaire, spirometry, peripheral blood eosinophil counts, and testing for airway responsiveness to histamine. Skin tests were performed only at study onset. Regression splines were used to assess the effects of these variables on levels of FEV 1, VC, and the ratio of FEV1 to VC, with adjustment for age, height, and area of residence. Current (-44 ml/pack/day) and cumulative (-85 ml/10 packs/year) cigarette smoking were significant predictors of reduced maximal level of FEV1 in males but not in females. The presence of respiratory symptoms (-114 ml in males, -106 ml in females), increased eosinophils (-128 ml [males], -53 ml [females]), and increased airway responsiveness (-225 ml [males], -213 ml [females]) were all significant predictors of reduced level of FEV1. To the degree that these factors diminished plateau phase pulmonary function, they may be important predictors of chronic obstructive pulmonary disease in later life.

Original languageEnglish (US)
Pages (from-to)941-949
Number of pages9
JournalAmerican journal of respiratory and critical care medicine
Issue number8
StatePublished - Apr 15 2004
Externally publishedYes


  • Airway responsiveness
  • Asthma
  • Chronic obstructive pulmonary disease
  • Cigarette smoking

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Determinants of maximally attained level of pulmonary function'. Together they form a unique fingerprint.

Cite this