TY - JOUR
T1 - Determinants of malaria protective immunity in mice immunized with live sporozoites during trimethoprim-sulfamethoxazole prophylaxis
AU - Hobbs, Charlotte V.
AU - Sahu, Tejram
AU - Neal, Jillian
AU - Conteh, Solomon
AU - Voza, Tatiana
AU - Borkowsky, William
AU - Langhorne, Jean
AU - Duffy, Patrick E.
N1 - Publisher Copyright:
© 2021 by The American Society of Tropical Medicine and Hygiene
PY - 2021/2
Y1 - 2021/2
N2 - HIV and malaria geographically overlap. Trimethoprim-sulfamethoxazole (TMP-SMX) is a drug widely used in HIV-exposed uninfected and infected children in malaria-endemic areas, and is known to have antimalarial effects. Further study in terms of antimalarial impact and effect on development of malaria-specific immunity is therefore essential. Using rodent malaria models, we previously showed that repeated Plasmodium exposure during TMP-SMX administration, or chemoprophylaxis vaccination (CVac), induces CD8 T-cell-dependent preerythrocytic immunity. However, humoral immune responses have been shown to be important in models of preerythrocytic immunity. Herein, we demonstrate that antibody-mediated responses contribute to protective immunity induced by CVac immune sera using TMP-SMX in models of homologous, but not heterologous, parasite species. Clinical studies must account for potential anti-Plasmodium antibody induced during TMP-SMX prophylaxis.
AB - HIV and malaria geographically overlap. Trimethoprim-sulfamethoxazole (TMP-SMX) is a drug widely used in HIV-exposed uninfected and infected children in malaria-endemic areas, and is known to have antimalarial effects. Further study in terms of antimalarial impact and effect on development of malaria-specific immunity is therefore essential. Using rodent malaria models, we previously showed that repeated Plasmodium exposure during TMP-SMX administration, or chemoprophylaxis vaccination (CVac), induces CD8 T-cell-dependent preerythrocytic immunity. However, humoral immune responses have been shown to be important in models of preerythrocytic immunity. Herein, we demonstrate that antibody-mediated responses contribute to protective immunity induced by CVac immune sera using TMP-SMX in models of homologous, but not heterologous, parasite species. Clinical studies must account for potential anti-Plasmodium antibody induced during TMP-SMX prophylaxis.
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U2 - 10.4269/ajtmh.20-0749
DO - 10.4269/ajtmh.20-0749
M3 - Article
C2 - 33350377
AN - SCOPUS:85100883501
SN - 0002-9637
VL - 104
SP - 666
EP - 670
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 2
ER -