Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland

Benjamin J. Apelberg, Lynn R. Goldman, Antonia M. Calafat, Julie B. Herbstman, Zsuzsanna Kuklenyik, Jochen Heidler, Larry L. Needham, Rolf U. Halden, Frank R Witter

Research output: Contribution to journalArticle

Abstract

Polyfluoroalkyl compounds (PFCs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), are ubiquitous, man-made chemicals. Human data suggest that in utero exposures to these chemicals occur and some evidence of developmental toxicity in animals exists. To assess the distribution and determinants of fetal exposure to PFCs, we analyzed cord serum samples from 299 singleton newborns delivered between 2004 and 2005 in Baltimore, MD for 10 PFCs by employing on-line solid-phase extraction coupled with reversed-phase high-performance liquid chromatography-tandem mass spectrometry. PFOS and PFOA were detected in 99 and 100% of umbilical cord sera, with geometric mean concentrations of 4.9 and 1.6 ng/mL, respectively. PFOS and PFOA concentrations were highly correlated (Pearson's r = 0.64 after natural log transformation, p <0.01). Eight other PFCs were detected less frequently and at lower concentrations than PFOS and PFOA. Geometric mean concentrations of PFOS for Asians (6.0 ng/mL) and Blacks (5.1 ng/mL) were higher than those for Whites (4.2 ng/mL), while PFOA levels were more evenly distributed by race. Other maternal demographic and socioeconomic characteristics, including age, education, marital status, and living in the city limits were not significantly associated with cord concentrations. Our findings suggest that in utero exposure to PFOS and PFOA is ubiquitous in a population of babies born in Baltimore, MD.

Original languageEnglish (US)
Pages (from-to)3891-3897
Number of pages7
JournalEnvironmental Science and Technology
Volume41
Issue number11
DOIs
StatePublished - Jun 1 2007

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perfluorooctanoic acid
sulfonate
High performance liquid chromatography
Mass spectrometry
Toxicity
serum
Animals
Education
perfluorooctane sulfonic acid
exposure
liquid chromatography
mass spectrometry

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Science(all)
  • Environmental Chemistry

Cite this

Apelberg, B. J., Goldman, L. R., Calafat, A. M., Herbstman, J. B., Kuklenyik, Z., Heidler, J., ... Witter, F. R. (2007). Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland. Environmental Science and Technology, 41(11), 3891-3897. https://doi.org/10.1021/es0700911

Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland. / Apelberg, Benjamin J.; Goldman, Lynn R.; Calafat, Antonia M.; Herbstman, Julie B.; Kuklenyik, Zsuzsanna; Heidler, Jochen; Needham, Larry L.; Halden, Rolf U.; Witter, Frank R.

In: Environmental Science and Technology, Vol. 41, No. 11, 01.06.2007, p. 3891-3897.

Research output: Contribution to journalArticle

Apelberg, BJ, Goldman, LR, Calafat, AM, Herbstman, JB, Kuklenyik, Z, Heidler, J, Needham, LL, Halden, RU & Witter, FR 2007, 'Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland', Environmental Science and Technology, vol. 41, no. 11, pp. 3891-3897. https://doi.org/10.1021/es0700911
Apelberg BJ, Goldman LR, Calafat AM, Herbstman JB, Kuklenyik Z, Heidler J et al. Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland. Environmental Science and Technology. 2007 Jun 1;41(11):3891-3897. https://doi.org/10.1021/es0700911
Apelberg, Benjamin J. ; Goldman, Lynn R. ; Calafat, Antonia M. ; Herbstman, Julie B. ; Kuklenyik, Zsuzsanna ; Heidler, Jochen ; Needham, Larry L. ; Halden, Rolf U. ; Witter, Frank R. / Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland. In: Environmental Science and Technology. 2007 ; Vol. 41, No. 11. pp. 3891-3897.
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