Determinants of endothelial function in patients with COPD

Christian F. Clarenbach, Oliver Senn, Noriane A. Sievi, Giovanni Camen, Arnoldus J R Van Gestel, Valentina A. Rossi, Milo A. Puhan, Robert Thurnheer, Erich W. Russi, Malcolm Kohler

Research output: Contribution to journalArticle

Abstract

Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular mortality. Endothelial dysfunction may underpin this association. This cross-sectional study aimed to determine the impact of airflow obstruction, systemic inflammation, oxidative stress, sympathetic activation, hypoxaemia and physical activity on endothelial function in COPD. In stable COPD patients, assessments of endothelial function by flow-mediated dilatation (FMD), cardiovascular risk (Pocock score), airflow obstruction (forced expiratory volume in 1 s (FEV1)), systemic inflammation (high-sensitivity C-reactive protein and interleukin-6), oxidative stress (malondialdehyde), sympathetic activation (baroreflex sensitivity), hypoxaemia (arterial oxygen tension), hypercapnia (arterial carbon dioxide tension (PaCO2)), physical activity (steps per day) and exercise capacity (6-min walking distance) were performed. Associations between FMD and potential determinants were assessed in univariate and multivariate analyses. 106 patients (Global Initiative for Chronic Obstructive Lung Disease stage I/II 35%, stage III 25% and stage IV 40%) were included. In multivariate analysis FEV 1 was positively associated with FMD, independent of other significant FMD determinants from univariate analysis (sex, smoking, combined inhaled long-acting b-adrenergic and steroid medication, heart rate, baroreflex sensitivity and PaCO2) and adjusted for potential confounders (cardiovascular risk and age). In addition, the FMD and FEV1 association was modified by physical activity. The findings of this study demonstrate that the severity of airflow obstruction is a significant determinant of endothelial function in patients with COPD. A high level of physical activity seems to have a favourable effect on this association.

Original languageEnglish (US)
Pages (from-to)1194-1204
Number of pages11
JournalEuropean Respiratory Journal
Volume42
Issue number5
DOIs
StatePublished - Nov 1 2013

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Chronic Obstructive Pulmonary Disease
Dilatation
Exercise
Baroreflex
Forced Expiratory Volume
Oxidative Stress
Multivariate Analysis
Inflammation
Hypercapnia
Malondialdehyde
Carbon Dioxide
Adrenergic Agents
C-Reactive Protein
Walking
Interleukin-6
Arterial Pressure
Cross-Sectional Studies
Heart Rate
Smoking
Steroids

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Clarenbach, C. F., Senn, O., Sievi, N. A., Camen, G., Van Gestel, A. J. R., Rossi, V. A., ... Kohler, M. (2013). Determinants of endothelial function in patients with COPD. European Respiratory Journal, 42(5), 1194-1204. https://doi.org/10.1183/09031936.00144612

Determinants of endothelial function in patients with COPD. / Clarenbach, Christian F.; Senn, Oliver; Sievi, Noriane A.; Camen, Giovanni; Van Gestel, Arnoldus J R; Rossi, Valentina A.; Puhan, Milo A.; Thurnheer, Robert; Russi, Erich W.; Kohler, Malcolm.

In: European Respiratory Journal, Vol. 42, No. 5, 01.11.2013, p. 1194-1204.

Research output: Contribution to journalArticle

Clarenbach, CF, Senn, O, Sievi, NA, Camen, G, Van Gestel, AJR, Rossi, VA, Puhan, MA, Thurnheer, R, Russi, EW & Kohler, M 2013, 'Determinants of endothelial function in patients with COPD', European Respiratory Journal, vol. 42, no. 5, pp. 1194-1204. https://doi.org/10.1183/09031936.00144612
Clarenbach CF, Senn O, Sievi NA, Camen G, Van Gestel AJR, Rossi VA et al. Determinants of endothelial function in patients with COPD. European Respiratory Journal. 2013 Nov 1;42(5):1194-1204. https://doi.org/10.1183/09031936.00144612
Clarenbach, Christian F. ; Senn, Oliver ; Sievi, Noriane A. ; Camen, Giovanni ; Van Gestel, Arnoldus J R ; Rossi, Valentina A. ; Puhan, Milo A. ; Thurnheer, Robert ; Russi, Erich W. ; Kohler, Malcolm. / Determinants of endothelial function in patients with COPD. In: European Respiratory Journal. 2013 ; Vol. 42, No. 5. pp. 1194-1204.
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AU - Rossi, Valentina A.

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