Determinants of cardiovascular performance: Modification due to aging

Research output: Contribution to journalArticle

Abstract

With advancing age the ability of the cardiovascular system to respond to stress declines. The present discussion examines several mechanisms at both the organismal and cellular level that are known to determine cardiovascular performance, and analyses the current state of knowledge regarding the effect of aging on these processes. The conclusion reached is that aging does not result in a generalized decline in all parameters that regulate cardiovascular function, but rather a few specific functional deficits can be identified. Notably, these include a diminished responsiveness to catecholamines and altered vascular loading of the myocardium during high work load states.

Original languageEnglish (US)
Pages (from-to)15-30
Number of pages16
JournalJournal of Chronic Diseases
Volume36
Issue number1
DOIs
StatePublished - 1983
Externally publishedYes

Keywords

  • Aging
  • cardiac muscle
  • cardiovascular performance
  • catecholamines
  • excitation-contraction

ASJC Scopus subject areas

  • Epidemiology

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