Purpose: Recent advances in anterior segment imaging have enabled the measurement of novel ocular biometric parameters, such as lens vault (LV), posterior corneal arc length (PCAL), and iris area. The aims of this study were to identify the determinants of anterior chamber depth (ACD) and to ascertain the relative importance of these determinants in Chinese persons in Singapore. Design: Population-based, cross-sectional study. Participants: One thousand sixty Chinese participants recruited from the Singapore Chinese Eye Study. Methods: All subjects underwent AS optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA). Customized software (Zhongshan Angle Assessment Program, Guangzhou, China) was used to measure the AS-OCT parameters. Anterior chamber depth was determined using IOLMaster (Carl Zeiss Meditec). Univariate and multivariate regression analyses were performed to assess the association between ACD with ocular biometric and systemic parameters. A stepwise selection algorithm was used to identify sequentially the contribution of each independent variable. Main Outcome Measures: Anterior chamber depth and ocular biometric parameters. Results: The mean age (±standard deviation) of participants was 56.9±8.57 years and 50.5% were men. The mean ACD was 3.24±0.35 mm. The strongest determinants of ACD were LV (R 2 = 0.582; P2 = 0.186; P2 = 0.006), whereas lens thickness was not associated independently with ACD. Conclusions: Lens vault and PCAL explained 76.8% of the variability in ACD. When information about LV and PCAL were available, axial length was a poor determinant of ACD, whereas lens thickness was not associated independently with ACD. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
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