Determinants of airway responses to cat allergen: Comparison of environmental challenge to quantitative nasal and bronchial allergen challenge

S. H. Sicherer, Robert A Wood, P. A. Eggleston

Research output: Contribution to journalArticle

Abstract

Background: Why allergic subjects may have asthma or rhinitis on allergen exposure remains unclear. Objective: This study was carried out to compare airway responses during environmental allergen challenge (EAC) with quantitative allergen provocation challenges of the upper and lower airways. Methods: Thirteen subjects with allergy to cats underwent EAC to cats. Lower airway responses during EAC were compared with bronchoprovocation with allergen. Nasal mucosal challenge with allergen-soaked disks were compared with EAC nasal responses. Nonspecific bronchial reactivity was assessed with methacholine; allergen sensitivity was assessed by skin prick tests, RAST, and end-point skin titration. Results: During EAC, the maximal fall in FEV1 ranged from 6% to 57% (median, 18%) and correlated closely with allergen bronchoprovocation PD20 (Spearman's correlation coefficient [R(s)] = - 0.85, p <0.0002). EAC asthmatic responses and allergen bronchoprovocation correlated with methacholine PD20 (R(s) = -0.85, p = 0.0002 and R(s) = 0.83, p = 0.0004, respectively). Nasal provocation and EAC nasal responses correlated with each other but not with lower airway responses. On the basis of EAC and allergen bronchoprovocation responses, seven participants with asthma were identified. This group was significantly more sensitive to inhaled methacholine but was similar to the nonasthmatic group in IgE- mediated sensitivity and nasal responses. Conclusions: The lower respiratory tract is less responsive to allergic and nonallergic stimuli in persons with allergic rhinitis. In persons with asthma during EAC, the response to nebulized cat allergen is also abnormal and correlates closely with their abnormal responsiveness to nonimmunologic stimuli.

Original languageEnglish (US)
Pages (from-to)798-805
Number of pages8
JournalThe Journal of Allergy and Clinical Immunology
Volume99
Issue number6 I SUPPL.
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Bronchial Provocation Tests
Nose
Allergens
Cats
Methacholine Chloride
Asthma
Skin Test End-Point Titration

Keywords

  • Airway hyperreactivity
  • Asthma
  • Bronchoprovocation
  • Cat
  • Environmental allergen challenge
  • Rhinitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

@article{723c64635217497bb5001854b993ab25,
title = "Determinants of airway responses to cat allergen: Comparison of environmental challenge to quantitative nasal and bronchial allergen challenge",
abstract = "Background: Why allergic subjects may have asthma or rhinitis on allergen exposure remains unclear. Objective: This study was carried out to compare airway responses during environmental allergen challenge (EAC) with quantitative allergen provocation challenges of the upper and lower airways. Methods: Thirteen subjects with allergy to cats underwent EAC to cats. Lower airway responses during EAC were compared with bronchoprovocation with allergen. Nasal mucosal challenge with allergen-soaked disks were compared with EAC nasal responses. Nonspecific bronchial reactivity was assessed with methacholine; allergen sensitivity was assessed by skin prick tests, RAST, and end-point skin titration. Results: During EAC, the maximal fall in FEV1 ranged from 6{\%} to 57{\%} (median, 18{\%}) and correlated closely with allergen bronchoprovocation PD20 (Spearman's correlation coefficient [R(s)] = - 0.85, p <0.0002). EAC asthmatic responses and allergen bronchoprovocation correlated with methacholine PD20 (R(s) = -0.85, p = 0.0002 and R(s) = 0.83, p = 0.0004, respectively). Nasal provocation and EAC nasal responses correlated with each other but not with lower airway responses. On the basis of EAC and allergen bronchoprovocation responses, seven participants with asthma were identified. This group was significantly more sensitive to inhaled methacholine but was similar to the nonasthmatic group in IgE- mediated sensitivity and nasal responses. Conclusions: The lower respiratory tract is less responsive to allergic and nonallergic stimuli in persons with allergic rhinitis. In persons with asthma during EAC, the response to nebulized cat allergen is also abnormal and correlates closely with their abnormal responsiveness to nonimmunologic stimuli.",
keywords = "Airway hyperreactivity, Asthma, Bronchoprovocation, Cat, Environmental allergen challenge, Rhinitis",
author = "Sicherer, {S. H.} and Wood, {Robert A} and Eggleston, {P. A.}",
year = "1997",
doi = "10.1016/S0091-6749(97)80014-0",
language = "English (US)",
volume = "99",
pages = "798--805",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "6 I SUPPL.",

}

TY - JOUR

T1 - Determinants of airway responses to cat allergen

T2 - Comparison of environmental challenge to quantitative nasal and bronchial allergen challenge

AU - Sicherer, S. H.

AU - Wood, Robert A

AU - Eggleston, P. A.

PY - 1997

Y1 - 1997

N2 - Background: Why allergic subjects may have asthma or rhinitis on allergen exposure remains unclear. Objective: This study was carried out to compare airway responses during environmental allergen challenge (EAC) with quantitative allergen provocation challenges of the upper and lower airways. Methods: Thirteen subjects with allergy to cats underwent EAC to cats. Lower airway responses during EAC were compared with bronchoprovocation with allergen. Nasal mucosal challenge with allergen-soaked disks were compared with EAC nasal responses. Nonspecific bronchial reactivity was assessed with methacholine; allergen sensitivity was assessed by skin prick tests, RAST, and end-point skin titration. Results: During EAC, the maximal fall in FEV1 ranged from 6% to 57% (median, 18%) and correlated closely with allergen bronchoprovocation PD20 (Spearman's correlation coefficient [R(s)] = - 0.85, p <0.0002). EAC asthmatic responses and allergen bronchoprovocation correlated with methacholine PD20 (R(s) = -0.85, p = 0.0002 and R(s) = 0.83, p = 0.0004, respectively). Nasal provocation and EAC nasal responses correlated with each other but not with lower airway responses. On the basis of EAC and allergen bronchoprovocation responses, seven participants with asthma were identified. This group was significantly more sensitive to inhaled methacholine but was similar to the nonasthmatic group in IgE- mediated sensitivity and nasal responses. Conclusions: The lower respiratory tract is less responsive to allergic and nonallergic stimuli in persons with allergic rhinitis. In persons with asthma during EAC, the response to nebulized cat allergen is also abnormal and correlates closely with their abnormal responsiveness to nonimmunologic stimuli.

AB - Background: Why allergic subjects may have asthma or rhinitis on allergen exposure remains unclear. Objective: This study was carried out to compare airway responses during environmental allergen challenge (EAC) with quantitative allergen provocation challenges of the upper and lower airways. Methods: Thirteen subjects with allergy to cats underwent EAC to cats. Lower airway responses during EAC were compared with bronchoprovocation with allergen. Nasal mucosal challenge with allergen-soaked disks were compared with EAC nasal responses. Nonspecific bronchial reactivity was assessed with methacholine; allergen sensitivity was assessed by skin prick tests, RAST, and end-point skin titration. Results: During EAC, the maximal fall in FEV1 ranged from 6% to 57% (median, 18%) and correlated closely with allergen bronchoprovocation PD20 (Spearman's correlation coefficient [R(s)] = - 0.85, p <0.0002). EAC asthmatic responses and allergen bronchoprovocation correlated with methacholine PD20 (R(s) = -0.85, p = 0.0002 and R(s) = 0.83, p = 0.0004, respectively). Nasal provocation and EAC nasal responses correlated with each other but not with lower airway responses. On the basis of EAC and allergen bronchoprovocation responses, seven participants with asthma were identified. This group was significantly more sensitive to inhaled methacholine but was similar to the nonasthmatic group in IgE- mediated sensitivity and nasal responses. Conclusions: The lower respiratory tract is less responsive to allergic and nonallergic stimuli in persons with allergic rhinitis. In persons with asthma during EAC, the response to nebulized cat allergen is also abnormal and correlates closely with their abnormal responsiveness to nonimmunologic stimuli.

KW - Airway hyperreactivity

KW - Asthma

KW - Bronchoprovocation

KW - Cat

KW - Environmental allergen challenge

KW - Rhinitis

UR - http://www.scopus.com/inward/record.url?scp=0030914843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030914843&partnerID=8YFLogxK

U2 - 10.1016/S0091-6749(97)80014-0

DO - 10.1016/S0091-6749(97)80014-0

M3 - Article

C2 - 9215248

AN - SCOPUS:0030914843

VL - 99

SP - 798

EP - 805

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 6 I SUPPL.

ER -