Determinants and normal values of ascending aortic diameter by age, gender, and race/ethnicity in the Multi-Ethnic Study of Atherosclerosis (MESA)

Evrim B. Turkbey, Aditya Jain, Craig Johnson, Alban Redheuil, Andrew E. Arai, Antoinette S. Gomes, James Carr, W. Gregory Hundley, Gisela Teixido-Tura, John Eng, Joao Lima, David A. Bluemke

Research output: Contribution to journalArticle

Abstract

Purpose To determine the normal size and wall thickness of the ascending thoracic aorta (AA) and its relationship with cardiovascular risk factors in a large population-based study. Materials and Methods The mean AA luminal diameter was measured in 3573 Multi-Ethnic Study of Atherosclerosis (MESA) participants (age: 45-84 years), using gradient echo phase contrast cine MRI. Multiple linear regression models were used to evaluate the associations between risk factors and AA diameter. The median and upper normal limit (95th percentile) was defined in a "healthy" subgroup as well as AA wall thickness. Results The upper limits of body surface area indexed AA luminal diameter for age categories of 45-54, 55-64, 65-74, and 75-84 years are 21, 22, 22, and 28 mm/m2 in women and 20, 21, 22, 23 mm/m2 in men, respectively. The mean AA wall thickness was 2.8 mm. Age, gender, and body surface area were major determinants of AA luminal diameter (∼+1 mm/10 years; ∼+1.9 mm in men than women; ∼+1 mm/ 0.23 m2; P <0.001). The AA diameter in hypertensive subjects was +0.9 mm larger than in normotensives (P <0.001). Conclusion AA diameter increases gradually with aging for both genders among all race/ethnicities. The normal value of AA diameter is provided.

Original languageEnglish (US)
Pages (from-to)360-368
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume39
Issue number2
DOIs
StatePublished - Feb 2014

Fingerprint

Aorta
Atherosclerosis
Reference Values
Body Surface Area
Linear Models
Cine Magnetic Resonance Imaging
Thoracic Aorta
Population

Keywords

  • cardiovascular risk factors
  • MRI
  • normal value
  • thoracic aorta

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Determinants and normal values of ascending aortic diameter by age, gender, and race/ethnicity in the Multi-Ethnic Study of Atherosclerosis (MESA). / Turkbey, Evrim B.; Jain, Aditya; Johnson, Craig; Redheuil, Alban; Arai, Andrew E.; Gomes, Antoinette S.; Carr, James; Hundley, W. Gregory; Teixido-Tura, Gisela; Eng, John; Lima, Joao; Bluemke, David A.

In: Journal of Magnetic Resonance Imaging, Vol. 39, No. 2, 02.2014, p. 360-368.

Research output: Contribution to journalArticle

Turkbey, EB, Jain, A, Johnson, C, Redheuil, A, Arai, AE, Gomes, AS, Carr, J, Hundley, WG, Teixido-Tura, G, Eng, J, Lima, J & Bluemke, DA 2014, 'Determinants and normal values of ascending aortic diameter by age, gender, and race/ethnicity in the Multi-Ethnic Study of Atherosclerosis (MESA)', Journal of Magnetic Resonance Imaging, vol. 39, no. 2, pp. 360-368. https://doi.org/10.1002/jmri.24183
Turkbey, Evrim B. ; Jain, Aditya ; Johnson, Craig ; Redheuil, Alban ; Arai, Andrew E. ; Gomes, Antoinette S. ; Carr, James ; Hundley, W. Gregory ; Teixido-Tura, Gisela ; Eng, John ; Lima, Joao ; Bluemke, David A. / Determinants and normal values of ascending aortic diameter by age, gender, and race/ethnicity in the Multi-Ethnic Study of Atherosclerosis (MESA). In: Journal of Magnetic Resonance Imaging. 2014 ; Vol. 39, No. 2. pp. 360-368.
@article{66cd8458195c4ad28f2033c4dcb4657d,
title = "Determinants and normal values of ascending aortic diameter by age, gender, and race/ethnicity in the Multi-Ethnic Study of Atherosclerosis (MESA)",
abstract = "Purpose To determine the normal size and wall thickness of the ascending thoracic aorta (AA) and its relationship with cardiovascular risk factors in a large population-based study. Materials and Methods The mean AA luminal diameter was measured in 3573 Multi-Ethnic Study of Atherosclerosis (MESA) participants (age: 45-84 years), using gradient echo phase contrast cine MRI. Multiple linear regression models were used to evaluate the associations between risk factors and AA diameter. The median and upper normal limit (95th percentile) was defined in a {"}healthy{"} subgroup as well as AA wall thickness. Results The upper limits of body surface area indexed AA luminal diameter for age categories of 45-54, 55-64, 65-74, and 75-84 years are 21, 22, 22, and 28 mm/m2 in women and 20, 21, 22, 23 mm/m2 in men, respectively. The mean AA wall thickness was 2.8 mm. Age, gender, and body surface area were major determinants of AA luminal diameter (∼+1 mm/10 years; ∼+1.9 mm in men than women; ∼+1 mm/ 0.23 m2; P <0.001). The AA diameter in hypertensive subjects was +0.9 mm larger than in normotensives (P <0.001). Conclusion AA diameter increases gradually with aging for both genders among all race/ethnicities. The normal value of AA diameter is provided.",
keywords = "cardiovascular risk factors, MRI, normal value, thoracic aorta",
author = "Turkbey, {Evrim B.} and Aditya Jain and Craig Johnson and Alban Redheuil and Arai, {Andrew E.} and Gomes, {Antoinette S.} and James Carr and Hundley, {W. Gregory} and Gisela Teixido-Tura and John Eng and Joao Lima and Bluemke, {David A.}",
year = "2014",
month = "2",
doi = "10.1002/jmri.24183",
language = "English (US)",
volume = "39",
pages = "360--368",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Determinants and normal values of ascending aortic diameter by age, gender, and race/ethnicity in the Multi-Ethnic Study of Atherosclerosis (MESA)

AU - Turkbey, Evrim B.

AU - Jain, Aditya

AU - Johnson, Craig

AU - Redheuil, Alban

AU - Arai, Andrew E.

AU - Gomes, Antoinette S.

AU - Carr, James

AU - Hundley, W. Gregory

AU - Teixido-Tura, Gisela

AU - Eng, John

AU - Lima, Joao

AU - Bluemke, David A.

PY - 2014/2

Y1 - 2014/2

N2 - Purpose To determine the normal size and wall thickness of the ascending thoracic aorta (AA) and its relationship with cardiovascular risk factors in a large population-based study. Materials and Methods The mean AA luminal diameter was measured in 3573 Multi-Ethnic Study of Atherosclerosis (MESA) participants (age: 45-84 years), using gradient echo phase contrast cine MRI. Multiple linear regression models were used to evaluate the associations between risk factors and AA diameter. The median and upper normal limit (95th percentile) was defined in a "healthy" subgroup as well as AA wall thickness. Results The upper limits of body surface area indexed AA luminal diameter for age categories of 45-54, 55-64, 65-74, and 75-84 years are 21, 22, 22, and 28 mm/m2 in women and 20, 21, 22, 23 mm/m2 in men, respectively. The mean AA wall thickness was 2.8 mm. Age, gender, and body surface area were major determinants of AA luminal diameter (∼+1 mm/10 years; ∼+1.9 mm in men than women; ∼+1 mm/ 0.23 m2; P <0.001). The AA diameter in hypertensive subjects was +0.9 mm larger than in normotensives (P <0.001). Conclusion AA diameter increases gradually with aging for both genders among all race/ethnicities. The normal value of AA diameter is provided.

AB - Purpose To determine the normal size and wall thickness of the ascending thoracic aorta (AA) and its relationship with cardiovascular risk factors in a large population-based study. Materials and Methods The mean AA luminal diameter was measured in 3573 Multi-Ethnic Study of Atherosclerosis (MESA) participants (age: 45-84 years), using gradient echo phase contrast cine MRI. Multiple linear regression models were used to evaluate the associations between risk factors and AA diameter. The median and upper normal limit (95th percentile) was defined in a "healthy" subgroup as well as AA wall thickness. Results The upper limits of body surface area indexed AA luminal diameter for age categories of 45-54, 55-64, 65-74, and 75-84 years are 21, 22, 22, and 28 mm/m2 in women and 20, 21, 22, 23 mm/m2 in men, respectively. The mean AA wall thickness was 2.8 mm. Age, gender, and body surface area were major determinants of AA luminal diameter (∼+1 mm/10 years; ∼+1.9 mm in men than women; ∼+1 mm/ 0.23 m2; P <0.001). The AA diameter in hypertensive subjects was +0.9 mm larger than in normotensives (P <0.001). Conclusion AA diameter increases gradually with aging for both genders among all race/ethnicities. The normal value of AA diameter is provided.

KW - cardiovascular risk factors

KW - MRI

KW - normal value

KW - thoracic aorta

UR - http://www.scopus.com/inward/record.url?scp=84892694208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892694208&partnerID=8YFLogxK

U2 - 10.1002/jmri.24183

DO - 10.1002/jmri.24183

M3 - Article

VL - 39

SP - 360

EP - 368

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 2

ER -