Determinants and clinical significance of jugular venous valve competence

J. Fisher, F. Vaghaiwalla, J. Tsitlik, H. Levin, J. Brinker, M. Weisfeldt, F. Yin

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


The authors studied the function of right internal jugular vein valves during cardiac catheterization in 32 patients and external jugular vein valves in vitro from 13 dogs. Patients with normal central venous pressure had competent valves during cough-induced transvalvular pressure gradients of 52.4 ± 8.6 mm Hg. Ten of 15 patients with elevated central venous pressure had either incompetent or absent internal jugular valves, the latter occurring only in patients with long-standing, severe tricuspid regurgitation. During coughing, competent valves were also demonstrated in the left internal jugular and in the right and left subclavian veins. The excised canine valves were competent at a static transvalvular pressure of 81.8 ± 3.7 mm Hg. Five of 6 excised valves remained competent during pulsatile transvalvular pressure of 64.8 ± 1.9 mm Hg. Thus, thoracic inlet venous valves are usually competent during sudden increases in intrathoracic pressure. These valves may play an important role in establishing the extrathoracic arteriovenous pressure gradient necessary for forward blood flow during cardiopulmonary resuscitation and other states with high intrathoracic pressure.

Original languageEnglish (US)
Pages (from-to)188-196
Number of pages9
JournalUnknown Journal
Issue number1 I
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'Determinants and clinical significance of jugular venous valve competence'. Together they form a unique fingerprint.

Cite this