Detection of Taenia solium DNA in the urine of neurocysticercosis patients

for the Cysticercosis Working Group in Peru†

Research output: Contribution to journalArticle

Abstract

Neurocysticercosis (NCC), caused by Taenia solium larvae that reside in the central nervous system, results in serious public health and medical issues in many regions of the world. Current diagnosis of NCC is complex requiring both serology and costly neuroimaging of parasitic cysts in the brain. This diagnostic pipeline can be problematic in resource-constrained settings. There is an unmet need for a highly sensitive and clinically informative diagnostic test to complement the present diagnostic approaches. Here, we report that T. solium–derived cell-free DNA is readily detectable in the urine of patients with the subarachnoid and parenchymal forms of NCC, and discuss the potential utility of this approach in enhancing and refining T. solium diagnostics.

Original languageEnglish (US)
Pages (from-to)327-329
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume100
Issue number2
DOIs
StatePublished - Jan 1 2019

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

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