Detection of Spontaneous Postsynaptic Potentials

Piotr J. Franaszczuk, Gregory K. Bergey, Pawel Kudela

Research output: Contribution to journalArticle

Abstract

The amplitude and time course of postsynaptic potentials (PSPs) recorded by intracellular techniques contain information that allow different synaptic events to be detected. In the present paper an algorithm to detect spontaneous PSPs is described. The algorithm is based on computation of approximationof first and second derivatives of the signals. The method was tested on both computer-simulated potentials and on experimental data recorded from dissociated mouse spinal cord neurons in tissue culture. The receiver operating characteristics of the detection algorithm were computed. This method can be applied to investigations of dynamic changes in the activityof neural networks.

Original languageEnglish (US)
Pages (from-to)354-370
Number of pages17
JournalComputers and Biomedical Research
Volume28
Issue number5
DOIs
StatePublished - Oct 1995
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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