Detection of SNP-SNP interactions in trios of parents with schizophrenic children

Qing Li, M. Daniele Fallin, Thomas A. Louis, Virginia K. Lasseter, John A. McGrath, Dimitri Avramopoulos, Paula S. Wolyniec, David Valle, Kung Yee Liang, Ann E. Pulver, Ingo Ruczinski

Research output: Contribution to journalArticle

Abstract

Schizophrenia (SZ) is a heritable and complex psychiatric disorder with an estimated worldwide prevalence of about 1%. Research on the risk factors for SZ has thus far yielded few clues to causes, but has pointed to a heterogeneous etiology that likely involves multiple genes and gene-environment interactions. In this manuscript, we apply a novel method (trio logic regression, Li et al., 2009) to case-parent trio data from a SZ candidate gene study conducted on families of Ashkenazi Jewish descent, and demonstrate the method's ability to detect multi-gene models for SZ risk in the family-based design. In particular, we demonstrate how this method revealed a genotype-phenotype association that includes an allele without marginal effect.

Original languageEnglish (US)
Pages (from-to)396-406
Number of pages11
JournalGenetic epidemiology
Volume34
Issue number5
DOIs
StatePublished - Jul 1 2010

Keywords

  • Case-parent trios
  • Interaction
  • Logic regression
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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