Abstract
Schizophrenia (SZ) is a heritable and complex psychiatric disorder with an estimated worldwide prevalence of about 1%. Research on the risk factors for SZ has thus far yielded few clues to causes, but has pointed to a heterogeneous etiology that likely involves multiple genes and gene-environment interactions. In this manuscript, we apply a novel method (trio logic regression, Li et al., 2009) to case-parent trio data from a SZ candidate gene study conducted on families of Ashkenazi Jewish descent, and demonstrate the method's ability to detect multi-gene models for SZ risk in the family-based design. In particular, we demonstrate how this method revealed a genotype-phenotype association that includes an allele without marginal effect.
Original language | English (US) |
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Pages (from-to) | 396-406 |
Number of pages | 11 |
Journal | Genetic epidemiology |
Volume | 34 |
Issue number | 5 |
DOIs | |
State | Published - Jul 2010 |
Keywords
- Case-parent trios
- Interaction
- Logic regression
- Single nucleotide polymorphisms
ASJC Scopus subject areas
- Epidemiology
- Genetics(clinical)