Detection of Simulated Pulmonary Embolism in a Porcine Model Using Hyperpolarized 3He MRI

Aman Jalali, Masaru Ishii, Johan M. Edvinsson, Liang Guan, Maxim Itkin, David A. Lipson, James E. Baumgardner, Rahim R. Rizi

Research output: Contribution to journalArticlepeer-review


Several radiological imaging modalities are available to assist with the clinical diagnosis of pulmonary embolism (PE). The most frequently used techniques-nuclear medicine ventilation-perfusion (VP) scan, computed tomography (CT), magnetic resonance angiography (MRA), and pulmonary angiography (PA)-all have literature-supported, substantial limitations with respect to timeliness and patient safety. Hyperpolarized 3He magnetic resonance gas distribution imaging (HP 3He MRI) recently has shown potential as a safer and faster alternative. In this study, we performed HP 3He MRI on a porcine model (N = 6) of simulated PE using selective occlusion balloon catheterization (N = 4) and nonselective aged autologous clot injection (N = 1). The technique was also performed on a normal pig and again after the animal was killed. Temporal depletion of regional HP 3He MRI signal intensity provided for a qualitative assessment of simulated PE (N = 4), and regional PAO2 (alveolar partial pressure of oxygen) was calculated in affected airspaces for a quantitative assessment of simulated PE (N = 1). The preliminary results suggest that HP 3He MRI shows promise as a means of assessing regional pulmonary perfusion abnormalities in the porcine models of simulated PE that were used in this study.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalMagnetic resonance in medicine
Issue number2
StatePublished - Feb 2004


  • Gas distribution
  • Hyperpolarized He MRI
  • PO
  • Pulmonary embolism
  • Qualitative
  • Quantitative

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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