Abstract
Objectives To determine the concentrations of nicotine and nicotine metabolites in RBC units as a means to estimate the point prevalence of exposure within the healthy donor pool. Methods Segments from 105 RBC units were tested for the presence of nicotine, cotinine, or trans-3' -hydroxycotinine by liquid chromatography-tandem mass spectrometry. Results Of the 20 (19%) units that contained detectable concentrations of nicotine, cotinine, or trans-3' -hydroxycotinine, 19 (18.1%) contained concentrations consistent with the use of a nicotine-containing product within 48 hours of specimen collection. One RBC unit contained nicotine concentrations consistent with passive exposure. Conclusions Chemicals from nicotine-containing products are detectable within the US RBC supply. Further investigation is needed to determine the risks of transfusion-associated exposure to nicotine and other tobacco-associated chemicals among vulnerable patient populations such as neonates.
Original language | English (US) |
---|---|
Pages (from-to) | 516-521 |
Number of pages | 6 |
Journal | American journal of clinical pathology |
Volume | 151 |
Issue number | 5 |
DOIs | |
State | Published - Apr 2 2019 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine