Detection of neurologic injury using vascular reactivity monitoring and glial fibrillary acidic protein

Christopher J. Rhee, Kathleen K. Kibler, Ken M. Brady, Allen D Everett, Ernest M Graham, Dean B. Andropoulos, R. Blaine Easley

Research output: Contribution to journalArticle

Abstract

New noninvasive methods for monitoring cerebrovascular pressure reactivity coupled with a blood-based assay for brain-specific injury in preterm infants could allow early diagnosis of brain injury and set the stage for improved timing and effectiveness of interventions. Using an adaptation of near-infrared spectroscopy, we report a case of a very low birth weight infant undergoing hemoglobin volume index monitoring as a measure of cerebrovascular pressure reactivity. During the monitoring period, this infant demonstrated significant disturbances in cerebrovascular pressure reactivity that coincided with elevation of serum glial fibrillary acidic protein and new findings of brain injury on head ultrasound. This case report demonstrates the potential of emerging noninvasive monitoring methods to assist in both detection and therapeutic management to improve neurologic outcomes of the very low birth weight neonate.

Original languageEnglish (US)
JournalPediatrics
Volume131
Issue number3
DOIs
StatePublished - Mar 2013

Fingerprint

Nervous System Trauma
Glial Fibrillary Acidic Protein
Brain Injuries
Blood Vessels
Very Low Birth Weight Infant
Pressure
Near-Infrared Spectroscopy
Premature Infants
Nervous System
Blood Proteins
Early Diagnosis
Hemoglobins
Head
Newborn Infant
Protein
Reactivity
Monitoring
Therapeutics
Brain Injury

Keywords

  • Cerebrovascular pressure reactivity
  • Glial fibrillary acidic protein
  • Head ultrasound
  • Intraventricular hemorrhage
  • Prematurity
  • Very low birth weight

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Arts and Humanities (miscellaneous)

Cite this

Detection of neurologic injury using vascular reactivity monitoring and glial fibrillary acidic protein. / Rhee, Christopher J.; Kibler, Kathleen K.; Brady, Ken M.; Everett, Allen D; Graham, Ernest M; Andropoulos, Dean B.; Easley, R. Blaine.

In: Pediatrics, Vol. 131, No. 3, 03.2013.

Research output: Contribution to journalArticle

Rhee, Christopher J. ; Kibler, Kathleen K. ; Brady, Ken M. ; Everett, Allen D ; Graham, Ernest M ; Andropoulos, Dean B. ; Easley, R. Blaine. / Detection of neurologic injury using vascular reactivity monitoring and glial fibrillary acidic protein. In: Pediatrics. 2013 ; Vol. 131, No. 3.
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