Detection of melanoma metastases with the sentinel node biopsy: the legacy of Donald L. Morton, MD (1934–2014)

Research output: Contribution to journalArticlepeer-review

Abstract

Dr. Donald L. Morton was clearly the pioneer of the sentinel node biopsy, which was a major advance in oncology that has improved the management of cancer patients worldwide. He conducted a series of practice-changing clinical trials to validate the important staging role of the sentinel lymph node biopsy for melanoma, and also spawned other studies that demonstrated its staging value in multiple other cancer types, most notably in breast cancer, gastric cancer, and colorectal cancer. His many contributions in this field have provided a unique opportunity to study host/tumor relationships, since the sentinel lymph node is the first location were the host immune defenses are confronted with metastasis arising from the primary cancer.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalClinical and Experimental Metastasis
DOIs
StateAccepted/In press - May 31 2018
Externally publishedYes

Keywords

  • Clinical trials
  • Detection
  • Melanoma
  • Sentinel node biopsy
  • Staging

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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