Detection of isolated cerebrovascular β-amyloid with Pittsburgh compound B

Steven M. Greenberg, Thomas Grabowski, M. Edip Gurol, Maureen E. Skehan, R. N.Kaveer Nandigam, John A. Becker, Monica Garcia-Alloza, Claudia Prada, Matthew P. Frosch, Jonathan Rosand, Anand Viswanathan, Eric E. Smith, Keith A. Johnson

Research output: Contribution to journalArticlepeer-review

Abstract

Imaging of cerebrovascular β-amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42-year-old man with early manifestations of Iowa-type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no plaque deposits of fibrillar β-amyloid. The results demonstrated increased Pittsburgh Compound B retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer's disease. These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions.

Original languageEnglish (US)
Pages (from-to)587-591
Number of pages5
JournalAnnals of neurology
Volume64
Issue number5
DOIs
StatePublished - Nov 2008
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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