Abstract
Imaging of cerebrovascular β-amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42-year-old man with early manifestations of Iowa-type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no plaque deposits of fibrillar β-amyloid. The results demonstrated increased Pittsburgh Compound B retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer's disease. These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions.
Original language | English (US) |
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Pages (from-to) | 587-591 |
Number of pages | 5 |
Journal | Annals of neurology |
Volume | 64 |
Issue number | 5 |
DOIs | |
State | Published - Nov 2008 |
Externally published | Yes |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology