Abstract
The confirmation of human papillomavirus (HPV) as a causative agent for a subset of squamous cell carcinomas of the head and neck has resulted in a growing expectation for HPV testing in head and neck cancers. An increasing understanding of HPV-related tumorigenesis has informed this evaluation process in a manner that is moving wide scale, indiscriminant, and nonstandardized testing toward a more directed, clinically relevant, and standardized approach. This review addresses the current state of HPV detection and focuses on the importance, appropriate time, and need for HPV testing.
Original language | English (US) |
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Pages (from-to) | 765-777 |
Number of pages | 13 |
Journal | Otolaryngologic Clinics of North America |
Volume | 45 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2012 |
Keywords
- Hybrid capture 2
- In situ hybridization
- Oropharyngeal carcinoma
- P16 immunohistochemistry
- Squamous cell carcinoma of the head and neck
ASJC Scopus subject areas
- Otorhinolaryngology