Detection of genetic variance in blood pressure of seven-year-old twins

Richard J. Havlik, Robert J. Garrison, Solomon H. Katz, R. Curtis Ellison, Manning Feinleib, Ntinos C. Myrianthopoulos

Research output: Contribution to journalArticle

Abstract

Results from twin studies in older children and adults indicate that there is significant genetic variance for blood pressure (BP). Utilizing data which were collected in 12 US university-affiliated hospitals In 1966-1973 in the Collaborative Perinatal Project (NCPP), the authors sought to determine if the effects of heredity on BP variability are apparent in younger twins. BP was determined in 197 pairs of like-sexed twins at seven years of age. Significant genetic variability for diastolic blood pressure (DBP) was found in the twins, with a heritability estimate of 0.53. Systolic blood pressure (SBP) results tended in the same direction but were not statistically significant. The trends were comparable for both sexes and races. These findings suggest that even at a young age substantial genetic influences on DBP variability are detectable.

Original languageEnglish (US)
Pages (from-to)512-516
Number of pages5
JournalAmerican Journal of Epidemiology
Volume109
Issue number5
StatePublished - May 1979
Externally publishedYes

Keywords

  • Blood pressure
  • Genetics
  • Twins

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Fingerprint Dive into the research topics of 'Detection of genetic variance in blood pressure of seven-year-old twins'. Together they form a unique fingerprint.

  • Cite this

    Havlik, R. J., Garrison, R. J., Katz, S. H., Ellison, R. C., Feinleib, M., & Myrianthopoulos, N. C. (1979). Detection of genetic variance in blood pressure of seven-year-old twins. American Journal of Epidemiology, 109(5), 512-516.