Detection of filarial antigen in urine of humans with Wuchereria bancrofti infection by immunoradiometric assay

M. V.R. Reddy, B. C. Harinath, R. G. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

Human urine samples of different groups were analyzed for the presence of filarial antigen by immuno-radiometric assay (IRMA) using 125I-Rabbit IgG antibodies to B. malayi antigen. Six out of ten microfilaraemia, one out of five clinical filariasis had detectable antigen, while none of the endemic and non-endemic normals (n=12) were positive. The effect of heat-acid treatment on the detectability of antigen in the urine and serum was explored. Heat-acid treatment in general did not reduce the level of filarial antigen in the urine samples while there was a measurable reduction in the antigen levels in the sera.

Original languageEnglish (US)
Pages (from-to)515-519
Number of pages5
JournalIndian journal of experimental biology
Volume22
Issue number10
StatePublished - Dec 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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