DETECTION OF FEEDBACK IN THE CENTRAL NERVOUS SYSTEM OF PARKINSONIAN PATIENTS.

S. M. Schnider; R. H. Kwong; H. C. Kwan; F. A. Lenz

doi:10.1109/cdc.1986.267248

DETECTION OF FEEDBACK IN THE CENTRAL NERVOUS SYSTEM OF PARKINSONIAN PATIENTS.

S. M. Schnider, R. H. Kwong, H. C. Kwan, F. A. Lenz

Research output: Contribution to journal › Conference article › peer-review

Abstract

Closed-loop system identification techniques are applied to signals obtained from the central nervous system of human Parkinsonian patients. The question is posed as to whether feedback exists from tremor, via sensory inputs, to thalamic tremor cells which are thought to drive Parkinsonian tremor. Linear multivariable models are fitted to the data, and it is found that, in general, the relationship between tremor and cell activity is best described by a closed-loop system. The results are consistent with the hypothesis that Parkinsonian tremor is the result of an unstable reflex loop in the central nervous system. 16 refs.

Original language	English (US)
Pages (from-to)	291-294
Number of pages	4
Journal	Proceedings of the IEEE Conference on Decision and Control
DOIs	https://doi.org/10.1109/cdc.1986.267248
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Control and Systems Engineering
Modeling and Simulation
Control and Optimization

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title = "DETECTION OF FEEDBACK IN THE CENTRAL NERVOUS SYSTEM OF PARKINSONIAN PATIENTS.",

abstract = "Closed-loop system identification techniques are applied to signals obtained from the central nervous system of human Parkinsonian patients. The question is posed as to whether feedback exists from tremor, via sensory inputs, to thalamic tremor cells which are thought to drive Parkinsonian tremor. Linear multivariable models are fitted to the data, and it is found that, in general, the relationship between tremor and cell activity is best described by a closed-loop system. The results are consistent with the hypothesis that Parkinsonian tremor is the result of an unstable reflex loop in the central nervous system. 16 refs.",

author = "Schnider, {S. M.} and Kwong, {R. H.} and Kwan, {H. C.} and Lenz, {F. A.}",

year = "1986",

doi = "10.1109/cdc.1986.267248",

language = "English (US)",

pages = "291--294",

journal = "Proceedings of the IEEE Conference on Decision and Control",

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T1 - DETECTION OF FEEDBACK IN THE CENTRAL NERVOUS SYSTEM OF PARKINSONIAN PATIENTS.

AU - Schnider, S. M.

AU - Kwong, R. H.

AU - Kwan, H. C.

AU - Lenz, F. A.

PY - 1986

Y1 - 1986

N2 - Closed-loop system identification techniques are applied to signals obtained from the central nervous system of human Parkinsonian patients. The question is posed as to whether feedback exists from tremor, via sensory inputs, to thalamic tremor cells which are thought to drive Parkinsonian tremor. Linear multivariable models are fitted to the data, and it is found that, in general, the relationship between tremor and cell activity is best described by a closed-loop system. The results are consistent with the hypothesis that Parkinsonian tremor is the result of an unstable reflex loop in the central nervous system. 16 refs.

AB - Closed-loop system identification techniques are applied to signals obtained from the central nervous system of human Parkinsonian patients. The question is posed as to whether feedback exists from tremor, via sensory inputs, to thalamic tremor cells which are thought to drive Parkinsonian tremor. Linear multivariable models are fitted to the data, and it is found that, in general, the relationship between tremor and cell activity is best described by a closed-loop system. The results are consistent with the hypothesis that Parkinsonian tremor is the result of an unstable reflex loop in the central nervous system. 16 refs.

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JO - Proceedings of the IEEE Conference on Decision and Control

JF - Proceedings of the IEEE Conference on Decision and Control

SN - 0191-2216

ER -

DETECTION OF FEEDBACK IN THE CENTRAL NERVOUS SYSTEM OF PARKINSONIAN PATIENTS.

Abstract

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