Abstract
Closed-loop system identification techniques are applied to signals obtained from the central nervous system of human Parkinsonian patients. The question is posed as to whether feedback exists from tremor, via sensory inputs, to thalamic tremor cells which are thought to drive Parkinsonian tremor. Linear multivariable models are fitted to the data, and it is found that, in general, the relationship between tremor and cell activity is best described by a closed-loop system. The results are consistent with the hypothesis that Parkinsonian tremor is the result of an unstable reflex loop in the central nervous system. 16 refs.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of the IEEE Conference on Decision and Control |
| Publisher | IEEE |
| Pages | 291-294 |
| Number of pages | 4 |
| State | Published - 1986 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Chemical Health and Safety
- Control and Systems Engineering
- Safety, Risk, Reliability and Quality
Cite this
DETECTION OF FEEDBACK IN THE CENTRAL NERVOUS SYSTEM OF PARKINSONIAN PATIENTS. / Schnider, S. M.; Kwong, R. H.; Kwan, H. C.; Lenz, Frederick.
Proceedings of the IEEE Conference on Decision and Control. IEEE, 1986. p. 291-294.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - DETECTION OF FEEDBACK IN THE CENTRAL NERVOUS SYSTEM OF PARKINSONIAN PATIENTS.
AU - Schnider, S. M.
AU - Kwong, R. H.
AU - Kwan, H. C.
AU - Lenz, Frederick
PY - 1986
Y1 - 1986
N2 - Closed-loop system identification techniques are applied to signals obtained from the central nervous system of human Parkinsonian patients. The question is posed as to whether feedback exists from tremor, via sensory inputs, to thalamic tremor cells which are thought to drive Parkinsonian tremor. Linear multivariable models are fitted to the data, and it is found that, in general, the relationship between tremor and cell activity is best described by a closed-loop system. The results are consistent with the hypothesis that Parkinsonian tremor is the result of an unstable reflex loop in the central nervous system. 16 refs.
AB - Closed-loop system identification techniques are applied to signals obtained from the central nervous system of human Parkinsonian patients. The question is posed as to whether feedback exists from tremor, via sensory inputs, to thalamic tremor cells which are thought to drive Parkinsonian tremor. Linear multivariable models are fitted to the data, and it is found that, in general, the relationship between tremor and cell activity is best described by a closed-loop system. The results are consistent with the hypothesis that Parkinsonian tremor is the result of an unstable reflex loop in the central nervous system. 16 refs.
UR - http://www.scopus.com/inward/record.url?scp=0022957374&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022957374&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:0022957374
SP - 291
EP - 294
BT - Proceedings of the IEEE Conference on Decision and Control
PB - IEEE
ER -