Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature

Ali Basiri, Daniel L. Edelstein, Jenna Graham, Afshin Nabili, Francis M Giardiello, Jessica C. Ramella-Roman

Research output: Contribution to journalArticle

Abstract

Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. We investigated a novel spectro-polarimetric imaging system capable of capturing high-resolution images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Results of a clinical trial show that the system is capable of separating FAP positive individuals from controls by measuring the individuals' oral vascular density and complexity.

Original languageEnglish (US)
Pages (from-to)707-714
Number of pages8
JournalJournal of Biophotonics
Volume4
Issue number10
DOIs
StatePublished - Oct 2011

Fingerprint

Adenomatous Polyposis Coli
Mouth Mucosa
Spectrum Analysis
Spectroscopy
Image resolution
Imaging systems
spectroscopy
cancer
Colonic Polyps
life (durability)
Wavelength
evaluation
high resolution
Genetic Testing
Testing
wavelengths
Blood Vessels
Colorectal Neoplasms
Clinical Trials
Mucous Membrane

Keywords

  • Colon cancer
  • Oral mucosa
  • Reflectance
  • Vessel density

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)
  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature. / Basiri, Ali; Edelstein, Daniel L.; Graham, Jenna; Nabili, Afshin; Giardiello, Francis M; Ramella-Roman, Jessica C.

In: Journal of Biophotonics, Vol. 4, No. 10, 10.2011, p. 707-714.

Research output: Contribution to journalArticle

Basiri, Ali ; Edelstein, Daniel L. ; Graham, Jenna ; Nabili, Afshin ; Giardiello, Francis M ; Ramella-Roman, Jessica C. / Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature. In: Journal of Biophotonics. 2011 ; Vol. 4, No. 10. pp. 707-714.
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