Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature

Ali Basiri, Daniel L. Edelstein, Jenna Graham, Afshin Nabili, Francis M. Giardiello, Jessica C. Ramella-Roman

Research output: Contribution to journalArticlepeer-review

Abstract

Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. We investigated a novel spectro-polarimetric imaging system capable of capturing high-resolution images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Results of a clinical trial show that the system is capable of separating FAP positive individuals from controls by measuring the individuals' oral vascular density and complexity.

Original languageEnglish (US)
Pages (from-to)707-714
Number of pages8
JournalJournal of biophotonics
Volume4
Issue number10
DOIs
StatePublished - Oct 2011

Keywords

  • Colon cancer
  • Oral mucosa
  • Reflectance
  • Vessel density

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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