Twenty American patients with Burkitt's lymphoma (BL) were studied serologically and biochemically to detect an association with Epstein Barr virus (EBV). A wide range of antibody reactivities was encountered. Five patients had serological profiles similar to those of African patients with BL: 1 and possibly 2 of these patients harbored EBV-DNA in their tumors. Fifteen patients had low or absent antibody to EBV: tumors from 10 of these patients lacked evidence of EBV-DNA. An unexplained association between elevated antibody (≥1:80) to EBV virus capsid antigen (VCA) and a favorable prognosis was noted in this series; this prognostic observation requires further substantiation. Thus, it appears that EBV associated BL is inversely proportional to tumor endemicity. An etiological role for EBV in BL remains speculative.
|Original language||English (US)|
|Number of pages||6|
|Journal||International Journal of Cancer|
|State||Published - 1976|
ASJC Scopus subject areas
- Cancer Research