Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver. Chaudhary AK, Nokubo M, Reddy GR, Yeola SN, Morrow JD, Blair IA, Marnett LJ. Science 1994; 265: 1580-1581

Kathleen Schwarz

doi:10.1016/0270-9139(95)90483-2

Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver. Chaudhary AK, Nokubo M, Reddy GR, Yeola SN, Morrow JD, Blair IA, Marnett LJ. Science 1994; 265: 1580-1581

Kathleen Schwarz

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Endogenous DNA adducts may contribute to the etiology of human genetic disease and cancer. One potential source of endogenous DNA adducts is lipid peroxidation, which generates mutagenic carbonyl compounds such as malondialdehyde. A sensitive mass spectrometric method permitted detection and quantitation of the major malondialdehyde-DNA adduct, a pyrimidopurinone derived from deoxyguanosine. DNA from disease-free human liver was found to contain 5400 adducts per cell, a frequency comparable to that of adducts formed by exogenous carcinogens. Reprinted with permission from Science 1994; 265: 1580-1581. Copyright 1994 American Association for the Advancement of Science.

Original language	English (US)
Pages (from-to)	1743-1745
Number of pages	3
Journal	Hepatology
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/0270-9139(95)90483-2
State	Published - Jun 1995

ASJC Scopus subject areas

Hepatology

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10.1016/0270-9139(95)90483-2

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title = "Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver. Chaudhary AK, Nokubo M, Reddy GR, Yeola SN, Morrow JD, Blair IA, Marnett LJ. Science 1994; 265: 1580-1581",

abstract = "Endogenous DNA adducts may contribute to the etiology of human genetic disease and cancer. One potential source of endogenous DNA adducts is lipid peroxidation, which generates mutagenic carbonyl compounds such as malondialdehyde. A sensitive mass spectrometric method permitted detection and quantitation of the major malondialdehyde-DNA adduct, a pyrimidopurinone derived from deoxyguanosine. DNA from disease-free human liver was found to contain 5400 adducts per cell, a frequency comparable to that of adducts formed by exogenous carcinogens. Reprinted with permission from Science 1994; 265: 1580-1581. Copyright 1994 American Association for the Advancement of Science.",

author = "Kathleen Schwarz",

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AU - Schwarz, Kathleen

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N2 - Endogenous DNA adducts may contribute to the etiology of human genetic disease and cancer. One potential source of endogenous DNA adducts is lipid peroxidation, which generates mutagenic carbonyl compounds such as malondialdehyde. A sensitive mass spectrometric method permitted detection and quantitation of the major malondialdehyde-DNA adduct, a pyrimidopurinone derived from deoxyguanosine. DNA from disease-free human liver was found to contain 5400 adducts per cell, a frequency comparable to that of adducts formed by exogenous carcinogens. Reprinted with permission from Science 1994; 265: 1580-1581. Copyright 1994 American Association for the Advancement of Science.

AB - Endogenous DNA adducts may contribute to the etiology of human genetic disease and cancer. One potential source of endogenous DNA adducts is lipid peroxidation, which generates mutagenic carbonyl compounds such as malondialdehyde. A sensitive mass spectrometric method permitted detection and quantitation of the major malondialdehyde-DNA adduct, a pyrimidopurinone derived from deoxyguanosine. DNA from disease-free human liver was found to contain 5400 adducts per cell, a frequency comparable to that of adducts formed by exogenous carcinogens. Reprinted with permission from Science 1994; 265: 1580-1581. Copyright 1994 American Association for the Advancement of Science.

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Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver. Chaudhary AK, Nokubo M, Reddy GR, Yeola SN, Morrow JD, Blair IA, Marnett LJ. Science 1994; 265: 1580-1581

Abstract

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