Detection of EBV DNA in the cord blood donor for a patient developing Epstein-Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation

P. R. Haut; P. Kovarik; P. H. Shaw; D. Walterhouse; H. B. Jenson; M. Kletzel

doi:10.1038/sj.bmt.1702770

Detection of EBV DNA in the cord blood donor for a patient developing Epstein-Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation

P. R. Haut, P. Kovarik, P. H. Shaw, D. Walterhouse, H. B. Jenson, M. Kletzel

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Epstein-Barr virus-associated post-transplant lymphoproliferative disorder (PTLD) has been well described as a complication following allogeneic stem cell transplantation but has only recently been reported following umbilical cord blood (UCB) transplant. We report the case of a child transplanted with unrelated mismatched UCB for juvenile chronic myelogenous leukemia (JCML) who developed EBV-associated PTLD, which was confirmed pathologically, 139 days following stem cell infusion. There was no clinical response to reduction of immune suppression, high-dose acyclovir, or alpha interferon. The patient died 160 days after transplantation. EBV was detected by polymerase chain reaction in the cord blood unit used for transplantation. This case demonstrates that EBV-associated PTLD can occur following mismatched unrelated UCB transplant and may be related to transmission of EBV infection by donor lymphocytes.

Original language	English (US)
Pages (from-to)	761-765
Number of pages	5
Journal	Bone marrow transplantation
Volume	27
Issue number	7
DOIs	https://doi.org/10.1038/sj.bmt.1702770
State	Published - 2001
Externally published	Yes

Keywords

EBV
PTLD
Transplant
Umbilical cord blood

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1702770

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Haut, P. R., Kovarik, P., Shaw, P. H., Walterhouse, D., Jenson, H. B., & Kletzel, M. (2001). Detection of EBV DNA in the cord blood donor for a patient developing Epstein-Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation. Bone marrow transplantation, 27(7), 761-765. https://doi.org/10.1038/sj.bmt.1702770

Detection of EBV DNA in the cord blood donor for a patient developing Epstein-Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation. / Haut, P. R.; Kovarik, P.; Shaw, P. H. et al.
In: Bone marrow transplantation, Vol. 27, No. 7, 2001, p. 761-765.

Research output: Contribution to journal › Article › peer-review

Haut, PR, Kovarik, P, Shaw, PH, Walterhouse, D, Jenson, HB & Kletzel, M 2001, 'Detection of EBV DNA in the cord blood donor for a patient developing Epstein-Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation', Bone marrow transplantation, vol. 27, no. 7, pp. 761-765. https://doi.org/10.1038/sj.bmt.1702770

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title = "Detection of EBV DNA in the cord blood donor for a patient developing Epstein-Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation",

abstract = "Epstein-Barr virus-associated post-transplant lymphoproliferative disorder (PTLD) has been well described as a complication following allogeneic stem cell transplantation but has only recently been reported following umbilical cord blood (UCB) transplant. We report the case of a child transplanted with unrelated mismatched UCB for juvenile chronic myelogenous leukemia (JCML) who developed EBV-associated PTLD, which was confirmed pathologically, 139 days following stem cell infusion. There was no clinical response to reduction of immune suppression, high-dose acyclovir, or alpha interferon. The patient died 160 days after transplantation. EBV was detected by polymerase chain reaction in the cord blood unit used for transplantation. This case demonstrates that EBV-associated PTLD can occur following mismatched unrelated UCB transplant and may be related to transmission of EBV infection by donor lymphocytes.",

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AB - Epstein-Barr virus-associated post-transplant lymphoproliferative disorder (PTLD) has been well described as a complication following allogeneic stem cell transplantation but has only recently been reported following umbilical cord blood (UCB) transplant. We report the case of a child transplanted with unrelated mismatched UCB for juvenile chronic myelogenous leukemia (JCML) who developed EBV-associated PTLD, which was confirmed pathologically, 139 days following stem cell infusion. There was no clinical response to reduction of immune suppression, high-dose acyclovir, or alpha interferon. The patient died 160 days after transplantation. EBV was detected by polymerase chain reaction in the cord blood unit used for transplantation. This case demonstrates that EBV-associated PTLD can occur following mismatched unrelated UCB transplant and may be related to transmission of EBV infection by donor lymphocytes.

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Detection of EBV DNA in the cord blood donor for a patient developing Epstein-Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation

Abstract

Keywords

ASJC Scopus subject areas

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