Detection of dural involvement by magnetic resonance imaging in adult patients with acute leukemias - preliminary experience

C. Y. Wu, J. L. Tang, Y. C. Chen, H. F. Tien, M. T. Lin, M. Yao, H. M. Liu

Research output: Contribution to journalArticle

Abstract

Retrospectively, the dura in 18 adult patients with acute leukemia were evaluated by gadolinium-enhanced T1-weighted magnetic resonance imaging (MRI). Abnormal dural enhancements were detected in three of four patients with positive cerebrospinal fluid (CSF) cytology, in one of five with suspicious central nervous system (CNS) disease, and in two of nine asymptomatic patients. Computed tomography failed to demonstrate any dural abnormality in these six patients. The abnormal dural enhancement was found in either (a) the brain and the spine, (b) the thoracolumbar spine, or (c) the area adjacent to the parenchymal lesions. Three of the patients were in hematological remission stage; disappearance of the abnormal dural enhancement was observed 1-2 months after radiotherapy and high-dose systemic chemotherapy. The results suggest that MRI is a sensitive and noninvasive imaging modality and superior to CT in detecting dural disease in leukemic patients.

Original languageEnglish (US)
Pages (from-to)243-249
Number of pages7
JournalAnnals of hematology
Volume70
Issue number5
DOIs
StatePublished - May 1 1995
Externally publishedYes

Keywords

  • Acute leukemia
  • Dura
  • MRI

ASJC Scopus subject areas

  • Hematology

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