Detection of CTX-M-27 b-lactamase genes on two distinct plasmid types in ST38 Escherichia coli from three U.S. states

Andrew Cameron, Rupinder Mangat, Heba H. Mostafa, Samantha Taffner, Jun Wang, Ghinwa Dumyati, Richard A. Stanton, Jonathan B. Daniels, Davina Campbell, Joseph D. Lutgring, Nicole D. Pecora

Research output: Contribution to journalArticlepeer-review

Abstract

Infections caused by extended-spectrum-b-lactamase (ESBL)-producing Escherichia coli are a significant cause of morbidity and health care costs. Globally, the prevailing clonal type is ST131 in association with the blaCTX-M-15 b-lactamase gene. However, other ESBLs, such as blaCTX-M-14 and blaCTX-M-27, can also be prevalent in some regions. We identified ST38 ESBL-producing E. coli from different regions in the United States which carry blaCTX-M-27 embedded on two distinct plasmid types, suggesting the potential emergence of new ESBL lineages.

Original languageEnglish (US)
Article numbere00825-21
JournalAntimicrobial agents and chemotherapy
Volume65
Issue number7
DOIs
StatePublished - Jul 2021

Keywords

  • B-lactamases
  • CTX-M-27
  • Ceftriaxone
  • ESBL
  • Escherichia coli
  • Extended-spectrum b-lactamases
  • IncF plasmid
  • ST38

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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