TY - JOUR
T1 - Detection of coronary artery disease and the role of traditional risk factors in the Hopkins Lupus Cohort
AU - Petri, M.
PY - 2000
Y1 - 2000
N2 - Coronary artery disease (CAD) is a major cause of morbidity and mortality in SLE, including the Hopkins Lupus Cohort. Currently, 9% of the cohort have had clinical evidence (angina or myocardial infarction) of CAD. In our initial prospective study we found that duration of prednisone, hypertension, hyperlipidemia and obesity were risk factors for later CAD. We can now extend that list to include age, male sex, elevated homocysteine, renal insufficiency and antiphospholipid antibodies. Many of the risk factors are amenable to intervention, but the timing of intervention, and the effectiveness of intervention, must be determined.
AB - Coronary artery disease (CAD) is a major cause of morbidity and mortality in SLE, including the Hopkins Lupus Cohort. Currently, 9% of the cohort have had clinical evidence (angina or myocardial infarction) of CAD. In our initial prospective study we found that duration of prednisone, hypertension, hyperlipidemia and obesity were risk factors for later CAD. We can now extend that list to include age, male sex, elevated homocysteine, renal insufficiency and antiphospholipid antibodies. Many of the risk factors are amenable to intervention, but the timing of intervention, and the effectiveness of intervention, must be determined.
KW - Atherosclerosis
KW - Coronary artery disease
KW - Homocysteine
KW - Systemic lupus erythematosus
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U2 - 10.1191/096120300678828226
DO - 10.1191/096120300678828226
M3 - Review article
C2 - 10805483
AN - SCOPUS:0034109090
SN - 0961-2033
VL - 9
SP - 170
EP - 175
JO - Lupus
JF - Lupus
IS - 3
ER -