Detection of coronary artery disease and the role of traditional risk factors in the Hopkins Lupus Cohort

Research output: Contribution to journalReview articlepeer-review

Abstract

Coronary artery disease (CAD) is a major cause of morbidity and mortality in SLE, including the Hopkins Lupus Cohort. Currently, 9% of the cohort have had clinical evidence (angina or myocardial infarction) of CAD. In our initial prospective study we found that duration of prednisone, hypertension, hyperlipidemia and obesity were risk factors for later CAD. We can now extend that list to include age, male sex, elevated homocysteine, renal insufficiency and antiphospholipid antibodies. Many of the risk factors are amenable to intervention, but the timing of intervention, and the effectiveness of intervention, must be determined.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalLupus
Volume9
Issue number3
DOIs
StatePublished - 2000

Keywords

  • Atherosclerosis
  • Coronary artery disease
  • Homocysteine
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

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