Detection of chromosome 6 abnormalities in melanoma cell lines by chromosome arm painting probes

Xin Yuan Guan, Hongen Zhang, Jin Ming Yang, Jane Wang, Raymond Taetle, Paul S. Meltzer, Jeffrey M. Trent

Research output: Contribution to journalArticlepeer-review

Abstract

Chromosome 6 abnormalities, particularly the deletion of 6q, are among the mast frequent chromosomal changes in human malignant melonama. In this study, chromosome 6 rearrangements in 21 melanoma cell lines were identified by fluorescence in situ hybridization (FISH) with the use of chromosome 6 arm specific painting probes (CAPs). Structural abnormalities of chromosome 6 were detectable in 18 of 21 (86%) cases, including the identification of structural abnormalities that were not detectable by routine G-banding analysis. The results of this study correlate the frequency of 6q alterations and demonstrate that FISH with CAPs can be of considerable use for rapid screening of specific chromosome abnormalities in melanoma.

Original languageEnglish (US)
Pages (from-to)89-92
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume107
Issue number2
DOIs
StatePublished - Dec 1998

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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