Detection of Candida antigen in sera of patients with candidiasis by an enzyme-linked immunosorbent assay-inhibition technique

E. Segal, R. A. Berg, P. A. Pizzo, J. E. Bennett

Research output: Contribution to journalArticle

Abstract

A total of 37 serum samples from 27 cancer patients were tested by an enzyme-linked immunosorbent assay-inhibition technique for the detection of Candida antigen. In 20 randomly chosen sera from patients without clinical evidence of candidiasis and in 10 sera from patients proven by autopsy not to have candidiasis, the inhibition ranged up to 17%; in contrast inhibition ranged from 22 to 56% in all seven patients proven by autopsy to have systemic candidiasis, indicating the presence of Candida antigen in the sera of these patients. This technique appears promising in diagnosing disseminated candidiasis in cancer patients.

Original languageEnglish (US)
Pages (from-to)116-118
Number of pages3
JournalJournal of Clinical Microbiology
Volume10
Issue number1
StatePublished - 1979
Externally publishedYes

Fingerprint

Candidiasis
Candida
Enzyme-Linked Immunosorbent Assay
Antigens
Serum
Autopsy
Neoplasms

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Detection of Candida antigen in sera of patients with candidiasis by an enzyme-linked immunosorbent assay-inhibition technique. / Segal, E.; Berg, R. A.; Pizzo, P. A.; Bennett, J. E.

In: Journal of Clinical Microbiology, Vol. 10, No. 1, 1979, p. 116-118.

Research output: Contribution to journalArticle

@article{227bf3d1557d4adaa9bb70b007fc519a,
title = "Detection of Candida antigen in sera of patients with candidiasis by an enzyme-linked immunosorbent assay-inhibition technique",
abstract = "A total of 37 serum samples from 27 cancer patients were tested by an enzyme-linked immunosorbent assay-inhibition technique for the detection of Candida antigen. In 20 randomly chosen sera from patients without clinical evidence of candidiasis and in 10 sera from patients proven by autopsy not to have candidiasis, the inhibition ranged up to 17{\%}; in contrast inhibition ranged from 22 to 56{\%} in all seven patients proven by autopsy to have systemic candidiasis, indicating the presence of Candida antigen in the sera of these patients. This technique appears promising in diagnosing disseminated candidiasis in cancer patients.",
author = "E. Segal and Berg, {R. A.} and Pizzo, {P. A.} and Bennett, {J. E.}",
year = "1979",
language = "English (US)",
volume = "10",
pages = "116--118",
journal = "Journal of Clinical Microbiology",
issn = "0095-1137",
publisher = "American Society for Microbiology",
number = "1",

}

TY - JOUR

T1 - Detection of Candida antigen in sera of patients with candidiasis by an enzyme-linked immunosorbent assay-inhibition technique

AU - Segal, E.

AU - Berg, R. A.

AU - Pizzo, P. A.

AU - Bennett, J. E.

PY - 1979

Y1 - 1979

N2 - A total of 37 serum samples from 27 cancer patients were tested by an enzyme-linked immunosorbent assay-inhibition technique for the detection of Candida antigen. In 20 randomly chosen sera from patients without clinical evidence of candidiasis and in 10 sera from patients proven by autopsy not to have candidiasis, the inhibition ranged up to 17%; in contrast inhibition ranged from 22 to 56% in all seven patients proven by autopsy to have systemic candidiasis, indicating the presence of Candida antigen in the sera of these patients. This technique appears promising in diagnosing disseminated candidiasis in cancer patients.

AB - A total of 37 serum samples from 27 cancer patients were tested by an enzyme-linked immunosorbent assay-inhibition technique for the detection of Candida antigen. In 20 randomly chosen sera from patients without clinical evidence of candidiasis and in 10 sera from patients proven by autopsy not to have candidiasis, the inhibition ranged up to 17%; in contrast inhibition ranged from 22 to 56% in all seven patients proven by autopsy to have systemic candidiasis, indicating the presence of Candida antigen in the sera of these patients. This technique appears promising in diagnosing disseminated candidiasis in cancer patients.

UR - http://www.scopus.com/inward/record.url?scp=0018758042&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018758042&partnerID=8YFLogxK

M3 - Article

C2 - 387808

AN - SCOPUS:0018758042

VL - 10

SP - 116

EP - 118

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 1

ER -