Detection of At-Risk Pregnancy by Means of Highly Sensitive Assays for Thyroid Autoantibodies

Alex Stagnaro-Green, Sheila H. Roman, Rhoda H. Cobin, Essam Harazy, Michael Alvarez Marfany, Terry F. Davies

Research output: Contribution to journalArticle

Abstract

We screened 552 women who presented to their obstetrician in the first trimester of pregnancy using highly sensitive enzyme-linked immunosorbent assays for the presence of thyroglobulin and thyroidperoxidase autoantibodies and found an incidence of positivity of 19.6%. The tendency to secrete detectable levels of thyroid autoantibodies was significantly correlated with an increased rate of miscarriage. Thyroid autoantibody—positive women miscarried at a rate of 17%, compared with 8.4% for the autoantibody-negative women. Individual levels of thyroglobulin and thyroidperoxidase autoantibodies were similarly related to this increased miscarriage rate, with no evidence of autoantibody specificity in the relationship. Furthermore, the increase in miscarriages could not be explained by differences in thyroid hormone levels, the presence of cardiolipin autoantibodies, maternal age, gestational age at the time of maternal entry into the study, or previous obstetric history. We conclude that thyroid autoantibodies are an independent marker of “at-risk” pregnancy.

Original languageEnglish (US)
Pages (from-to)1422-1425
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume264
Issue number11
DOIs
StatePublished - Sep 19 1990
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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