Detection of Amyloid Plaques in Mouse Models of Alzheimer's Disease by Magnetic Resonance Imaging

Jiangyang Zhang; Paul Yarowsky; Marcia N. Gordon; Giovanni Di Carlo; Sanjay Munireddy; Peter C.M. Van Zijl; Susumu Mori

doi:10.1002/mrm.10730

Detection of Amyloid Plaques in Mouse Models of Alzheimer's Disease by Magnetic Resonance Imaging

Jiangyang Zhang, Paul Yarowsky, Marcia N. Gordon, Giovanni Di Carlo, Sanjay Munireddy, Peter C.M. Van Zijl, Susumu Mori

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We performed three-dimensional, high-resolution magnetic resonance imaging (MRI) of fixed mouse brains to determine whether MRI can detect amyloid plaques in transgenic mouse models of Alzheimer's disease. Plaque-like structures in the cortex and hippocampus could be clearly identified in T ₂-weighted images with an image resolution of 46 μm × 72 μm × 72 μm. The locations of plaques were confirmed in coregistration studies comparing MR images with Congo red-stained histological results. This technique is quantitative, less labor-intensive compared to histology, and is free from artifacts related to sectioning process (deformation and missing tissues). It enabled us to study the distribution of plaques in the entire brain in 3D. The results of this study suggest that this method may be useful for assessing treatment efficacy in mouse models of Alzheimer's disease (AD).

Original language	English (US)
Pages (from-to)	452-457
Number of pages	6
Journal	Magnetic resonance in medicine
Volume	51
Issue number	3
DOIs	https://doi.org/10.1002/mrm.10730
State	Published - Mar 2004

Keywords

Alzheimer's disease
Amyloid
MRI
Microimaging
Mouse
Plaque

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/mrm.10730

Cite this

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title = "Detection of Amyloid Plaques in Mouse Models of Alzheimer's Disease by Magnetic Resonance Imaging",

abstract = "We performed three-dimensional, high-resolution magnetic resonance imaging (MRI) of fixed mouse brains to determine whether MRI can detect amyloid plaques in transgenic mouse models of Alzheimer's disease. Plaque-like structures in the cortex and hippocampus could be clearly identified in T 2-weighted images with an image resolution of 46 μm × 72 μm × 72 μm. The locations of plaques were confirmed in coregistration studies comparing MR images with Congo red-stained histological results. This technique is quantitative, less labor-intensive compared to histology, and is free from artifacts related to sectioning process (deformation and missing tissues). It enabled us to study the distribution of plaques in the entire brain in 3D. The results of this study suggest that this method may be useful for assessing treatment efficacy in mouse models of Alzheimer's disease (AD).",

keywords = "Alzheimer's disease, Amyloid, MRI, Microimaging, Mouse, Plaque",

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AU - Zhang, Jiangyang

AU - Yarowsky, Paul

AU - Gordon, Marcia N.

AU - Di Carlo, Giovanni

AU - Munireddy, Sanjay

AU - Van Zijl, Peter C.M.

AU - Mori, Susumu

PY - 2004/3

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N2 - We performed three-dimensional, high-resolution magnetic resonance imaging (MRI) of fixed mouse brains to determine whether MRI can detect amyloid plaques in transgenic mouse models of Alzheimer's disease. Plaque-like structures in the cortex and hippocampus could be clearly identified in T 2-weighted images with an image resolution of 46 μm × 72 μm × 72 μm. The locations of plaques were confirmed in coregistration studies comparing MR images with Congo red-stained histological results. This technique is quantitative, less labor-intensive compared to histology, and is free from artifacts related to sectioning process (deformation and missing tissues). It enabled us to study the distribution of plaques in the entire brain in 3D. The results of this study suggest that this method may be useful for assessing treatment efficacy in mouse models of Alzheimer's disease (AD).

AB - We performed three-dimensional, high-resolution magnetic resonance imaging (MRI) of fixed mouse brains to determine whether MRI can detect amyloid plaques in transgenic mouse models of Alzheimer's disease. Plaque-like structures in the cortex and hippocampus could be clearly identified in T 2-weighted images with an image resolution of 46 μm × 72 μm × 72 μm. The locations of plaques were confirmed in coregistration studies comparing MR images with Congo red-stained histological results. This technique is quantitative, less labor-intensive compared to histology, and is free from artifacts related to sectioning process (deformation and missing tissues). It enabled us to study the distribution of plaques in the entire brain in 3D. The results of this study suggest that this method may be useful for assessing treatment efficacy in mouse models of Alzheimer's disease (AD).

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KW - Microimaging

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Detection of Amyloid Plaques in Mouse Models of Alzheimer's Disease by Magnetic Resonance Imaging

Abstract

Keywords

ASJC Scopus subject areas

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