Detection of adenocarcinoma by urinary microsatellite analysis after augmentation cystoplasty.

S. G. Docimo, N. H. Chow, G. Steiner, R. I. Silver, R. Rodriguez, S. Kinsman, David Sidransky, M. Schoenberg

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Abstract

Augmentation cystoplasty is associated with an increased risk of bladder cancer development between 10 and 20 years after augmentation. Using microsatellite analysis, we analyzed urine obtained before surgical resection of the malignant lesion from a patient who developed invasive adenocarcinoma after augmentation cystoplasty. Loss of heterozygosity was identified in both urine and tumor samples from this patient. This observation suggests that microsatellite urine analysis may be useful as a monitoring tool for patients after augmentation cystoplasty.

Original languageEnglish (US)
Pages (from-to)561
Number of pages1
JournalUrology
Volume54
Issue number3
Publication statusPublished - Sep 1999

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ASJC Scopus subject areas

  • Urology

Cite this

Docimo, S. G., Chow, N. H., Steiner, G., Silver, R. I., Rodriguez, R., Kinsman, S., ... Schoenberg, M. (1999). Detection of adenocarcinoma by urinary microsatellite analysis after augmentation cystoplasty. Urology, 54(3), 561.