Detection of acute myocardial ischemia using first-pass dynamics of MnDPDP on inversion recovery echoplanar imaging

Rolf Wyttenbach, Maythem Saeed, Michael F. Wendland, Jean François Geschwind, Jens Bremerich, Håkan Arheden, Charles B. Higgins

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Previous studies used manganese N,N'-bis-(pyridoxal 5- phosphate)ethylenediamine-N,N'-diacetic acid (MnDPDP) to detect myocardial ischemia at a dose of 0.4 mmol/kg with spin echo imaging. The purpose of this study was to detect acute myocardial ischemia using MnDPDP at a dose range near that approved for hepatobiliary imaging (0.005 mmol/kg) in conjunction with inversion recovery echoplanar imaging (IR EPI). Regional ischemia was produced in 26 rats by occluding the left coronary artery for 20-30 minutes before imaging. Consecutive 32 IR EP images (inversion time [TI]/TR/TE 700/2000/10 msec) were obtained to monitor the first pass of MnDPDP at four incremental doses (0.005, 0.01, 0.02, or 0.04 mmol/kg, n = 6-8). MnDPDP produced dose-dependent enhancement of left ventricular blood and normal myocardium, but not ischemic myocardium. Quantitative analysis revealed a difference in signal intensities (P < 0.05) between normal and ischemic myocardium at the time of peak enhancement in all groups. However, differential enhancement between normal and ischemic myocardium produced clear visual delineation of the ischemic region only at doses ≥0.01 mmol/kg. In conclusion, acute myocardial ischemia can be detected with IR EPI using doses close to the clinically approved dose of MnDPDP.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Issue number2
StatePublished - Feb 1999
Externally publishedYes


  • Contrast media
  • MRI
  • Manganese
  • Myocardial ischemia
  • Myocardial perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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