Detection limit enhancement of fluorescent heterogeneities in turbid media by dual-interfering excitation

Xavier Intes, Yu Chen, Xingde Li, Britton Chance

Research output: Contribution to journalArticle

Abstract

We report on a quantitative comparison between the single-source and the dual-interfering-source configurations for the detection of fluorescent heterogeneities embedded in a piecewise highly scattering homogeneous fluorescent background. The study is based on simulations with analytical solutions of the frequency-domain fluorescent diffuse photon density waves and practical signal-to-noise ratio considerations. Results show that dual-interfering sources outperform single-source techniques for the detection of heterogeneities in terms of fluorophore concentration and lifetime contrast. To detect the same inhomogeneity, less concentration and lifetime contrast is required with dual-interfering sources.

Original languageEnglish (US)
Pages (from-to)3999-4007
Number of pages9
JournalApplied Optics
Volume41
Issue number19
DOIs
StatePublished - Jul 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Detection limit enhancement of fluorescent heterogeneities in turbid media by dual-interfering excitation'. Together they form a unique fingerprint.

  • Cite this