Evidence for a causative relationship between dyslipidemia in children and adolescents and the early lesions of atherosclerosis in young adults is strong and internally consistent. Youth affected with dyslipidemia include those with single gene disorders such as familial hypercholesterolemia (FH), and those with oligogenic disorders such as familial combined hyperlipidemia (FCHL). In large populations of children followed up for several decades, the environmental and biologic contributions of elevated low-density lipoprotein (LDL) and obesity to the dyslipidemic phenotype and early subclinical atherosclerosis are impressive. Universal screening will be required for optimal detection and treatment of dyslipidemia and youth at risk for early atherosclerosis. This chapter provides an in-depth clinical and metabolic paradigm where a spectrum of dyslipidemia can be dissected and treated.
|Original language||English (US)|
|Title of host publication||Dyslipidemias|
|Subtitle of host publication||Pathophysiology, Evaluation and Management|
|Publisher||Humana Press Inc.|
|Number of pages||31|
|State||Published - Jan 1 2015|
ASJC Scopus subject areas