Detection and quantitation of human immunodeficiency virus type 1 using molecular DNA/RNA technology

J. B. Jackson

Research output: Contribution to journalArticle

Abstract

The direct detection and quantitation of human immunodeficiency virus type 1 are becoming increasingly important for diagnosis and viral load determinations in human immunodeficiency virus type 1 infection. Traditional molecular-based assays such as Southern, Northern, and in situ hybridization have had limited application in this area due to the relatively low number of proviral copies per cell, the low percentage of infected cells, and transcriptional dormancy in many of the infected cells. Recent technological advances in polymerase chain reaction assays promise a number of useful applications in the clinical research and clinical laboratory setting.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume117
Issue number5
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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