Detection and quantification of opiate receptors in Man by positron emission tomography. Potential applications to the study of pain

B. Sadzot, HS Mayberg, JJ Frost

Research output: Contribution to journalArticle

Abstract

Opiate receptors in the brain are the target of endogenous opioids and of exogenous synthetic opiates. It is well established that these receptors play a major role in the modulation of pain perception. With positron emission tomography (PET) and the appropriate radioligands, it is now possible to image and quantify neuroreceptors in vivo. We used 11C-diprenorphine and the extremely potent mu opiate receptor agonist 11C-carfentanil to image the distribution of opiate receptors in the human brain and to quantify their density, affinity, and occupancy. Several important methodological aspects of the in vivo opiate receptor labeling with PET in relation to the study of pain are considered in this paper. Monitoring receptor occupancy by opiate drugs as a function of pain relief has the potential to reveal better ways to treat pain.

Original languageEnglish (US)
Pages (from-to)323-334
Number of pages12
JournalNeurophysiologie Clinique
Volume20
Issue number5
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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