Detection and localization of surgically resectable cancers with a multi-analyte blood test

Joshua D. Cohen, Lu Li, Yuxuan Wang, Christopher Thoburn, Bahman Afsari, Liudmila V Danilova, Christopher Douville, Ammar A. Javed, Fay Wong, Austin Mattox, Ralph H Hruban, Christopher Wolfgang, Michael S Goggins, Marco Dal Molin, Tian-Li Wang, Richard S Roden, Alison Klein, Janine Ptak, Lisa Dobbyn, Joy SchaeferNatalie Silliman, Maria Popoli, Joshua T. Vogelstein, James D. Browne, Robert E. Schoen, Randall E. Brand, Jeanne Tie, Peter Gibbs, Hui Li Wong, Aaron S. Mansfield, Jin Jen, Samir M. Hanash, Massimo Falconi, Peter J. Allen, Shibin Zhou, Chetan Bettegowda, Luis A. Diaz, Cristian Tomasetti, Kenneth W Kinzler, Bert Vogelstein, Anne Marie O'Broin-Lennon, Nickolas Papadopoulos

Research output: Contribution to journalArticle

Abstract

Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients.

Original languageEnglish (US)
Pages (from-to)926-930
Number of pages5
JournalScience
Volume359
Issue number6378
DOIs
StatePublished - Feb 23 2018

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Hematologic Tests
Liver Neoplasms
Ovarian Neoplasms
Esophagus
Pancreas
Neoplasms
Stomach
Breast
Lung
Mutation
DNA
Proteins

ASJC Scopus subject areas

  • General

Cite this

Detection and localization of surgically resectable cancers with a multi-analyte blood test. / Cohen, Joshua D.; Li, Lu; Wang, Yuxuan; Thoburn, Christopher; Afsari, Bahman; Danilova, Liudmila V; Douville, Christopher; Javed, Ammar A.; Wong, Fay; Mattox, Austin; Hruban, Ralph H; Wolfgang, Christopher; Goggins, Michael S; Molin, Marco Dal; Wang, Tian-Li; Roden, Richard S; Klein, Alison; Ptak, Janine; Dobbyn, Lisa; Schaefer, Joy; Silliman, Natalie; Popoli, Maria; Vogelstein, Joshua T.; Browne, James D.; Schoen, Robert E.; Brand, Randall E.; Tie, Jeanne; Gibbs, Peter; Wong, Hui Li; Mansfield, Aaron S.; Jen, Jin; Hanash, Samir M.; Falconi, Massimo; Allen, Peter J.; Zhou, Shibin; Bettegowda, Chetan; Diaz, Luis A.; Tomasetti, Cristian; Kinzler, Kenneth W; Vogelstein, Bert; O'Broin-Lennon, Anne Marie; Papadopoulos, Nickolas.

In: Science, Vol. 359, No. 6378, 23.02.2018, p. 926-930.

Research output: Contribution to journalArticle

Cohen, JD, Li, L, Wang, Y, Thoburn, C, Afsari, B, Danilova, LV, Douville, C, Javed, AA, Wong, F, Mattox, A, Hruban, RH, Wolfgang, C, Goggins, MS, Molin, MD, Wang, T-L, Roden, RS, Klein, A, Ptak, J, Dobbyn, L, Schaefer, J, Silliman, N, Popoli, M, Vogelstein, JT, Browne, JD, Schoen, RE, Brand, RE, Tie, J, Gibbs, P, Wong, HL, Mansfield, AS, Jen, J, Hanash, SM, Falconi, M, Allen, PJ, Zhou, S, Bettegowda, C, Diaz, LA, Tomasetti, C, Kinzler, KW, Vogelstein, B, O'Broin-Lennon, AM & Papadopoulos, N 2018, 'Detection and localization of surgically resectable cancers with a multi-analyte blood test', Science, vol. 359, no. 6378, pp. 926-930. https://doi.org/10.1126/science.aar3247
Cohen, Joshua D. ; Li, Lu ; Wang, Yuxuan ; Thoburn, Christopher ; Afsari, Bahman ; Danilova, Liudmila V ; Douville, Christopher ; Javed, Ammar A. ; Wong, Fay ; Mattox, Austin ; Hruban, Ralph H ; Wolfgang, Christopher ; Goggins, Michael S ; Molin, Marco Dal ; Wang, Tian-Li ; Roden, Richard S ; Klein, Alison ; Ptak, Janine ; Dobbyn, Lisa ; Schaefer, Joy ; Silliman, Natalie ; Popoli, Maria ; Vogelstein, Joshua T. ; Browne, James D. ; Schoen, Robert E. ; Brand, Randall E. ; Tie, Jeanne ; Gibbs, Peter ; Wong, Hui Li ; Mansfield, Aaron S. ; Jen, Jin ; Hanash, Samir M. ; Falconi, Massimo ; Allen, Peter J. ; Zhou, Shibin ; Bettegowda, Chetan ; Diaz, Luis A. ; Tomasetti, Cristian ; Kinzler, Kenneth W ; Vogelstein, Bert ; O'Broin-Lennon, Anne Marie ; Papadopoulos, Nickolas. / Detection and localization of surgically resectable cancers with a multi-analyte blood test. In: Science. 2018 ; Vol. 359, No. 6378. pp. 926-930.
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AU - Cohen, Joshua D.

AU - Li, Lu

AU - Wang, Yuxuan

AU - Thoburn, Christopher

AU - Afsari, Bahman

AU - Danilova, Liudmila V

AU - Douville, Christopher

AU - Javed, Ammar A.

AU - Wong, Fay

AU - Mattox, Austin

AU - Hruban, Ralph H

AU - Wolfgang, Christopher

AU - Goggins, Michael S

AU - Molin, Marco Dal

AU - Wang, Tian-Li

AU - Roden, Richard S

AU - Klein, Alison

AU - Ptak, Janine

AU - Dobbyn, Lisa

AU - Schaefer, Joy

AU - Silliman, Natalie

AU - Popoli, Maria

AU - Vogelstein, Joshua T.

AU - Browne, James D.

AU - Schoen, Robert E.

AU - Brand, Randall E.

AU - Tie, Jeanne

AU - Gibbs, Peter

AU - Wong, Hui Li

AU - Mansfield, Aaron S.

AU - Jen, Jin

AU - Hanash, Samir M.

AU - Falconi, Massimo

AU - Allen, Peter J.

AU - Zhou, Shibin

AU - Bettegowda, Chetan

AU - Diaz, Luis A.

AU - Tomasetti, Cristian

AU - Kinzler, Kenneth W

AU - Vogelstein, Bert

AU - O'Broin-Lennon, Anne Marie

AU - Papadopoulos, Nickolas

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