Detection and localization of surgically resectable cancers with a multi-analyte blood test

Joshua D. Cohen, Lu Li, Yuxuan Wang, Christopher Thoburn, Bahman Afsari, Liudmila V Danilova, Christopher Douville, Ammar A. Javed, Fay Wong, Austin Mattox, Ralph H Hruban, Christopher Wolfgang, Michael S Goggins, Marco Dal Molin, Tian-Li Wang, Richard S Roden, Alison Klein, Janine Ptak, Lisa Dobbyn, Joy SchaeferNatalie Silliman, Maria Popoli, Joshua T. Vogelstein, James D. Browne, Robert E. Schoen, Randall E. Brand, Jeanne Tie, Peter Gibbs, Hui Li Wong, Aaron S. Mansfield, Jin Jen, Samir M. Hanash, Massimo Falconi, Peter J. Allen, Shibin Zhou, Chetan Bettegowda, Luis A. Diaz, Cristian Tomasetti, Kenneth W Kinzler, Bert Vogelstein, Anne Marie O'Broin-Lennon, Nickolas Papadopoulos

Research output: Contribution to journalArticle

Abstract

Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients.

Original languageEnglish (US)
Pages (from-to)926-930
Number of pages5
JournalScience
Volume359
Issue number6378
DOIs
StatePublished - Feb 23 2018

ASJC Scopus subject areas

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