Detection and characterization of human group C rotaviruses in Bangladesh

Mustafizur Rahman, Sukalyani Banik, Abu S.G. Faruque, Koki Taniguchi, David A. Sack, Marc Van Ranst, Tasnim Azim

Research output: Contribution to journalArticlepeer-review

Abstract

Group C rotaviruses were detected by reverse transcription-PCR in 14 (2.3%) of 611 group A rotavirus-negative stool specimens from the patients admitted to the International Centre for Diarrhoeal Disease Research, Bangladesh hospital, Dhaka, Bangladesh, during July to December 2003. The low rate of detection suggested that infection with group C rotaviruses was an uncommon cause of liospitalization due to gastroenteritis. In addition, coinfections with pathogenic enteric bacteria were frequently observed in group C rotavirus-infected patients. Nucleotide sequence comparison of the VP4, VP6, and W7 genes revealed that the Bangladeshi group C rotaviruses were most similar to Nigerian group C rotavirus strains. Phylogenetic analysis suggested that all human group C rotaviruses, including the strains isolated in our study, clustered in a monophyletic branch, which was distantly related to the branch comprised of animal group C rotaviruses.

Original languageEnglish (US)
Pages (from-to)4460-4465
Number of pages6
JournalJournal of clinical microbiology
Volume43
Issue number9
DOIs
StatePublished - Sep 2005
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)

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