Detecting volumetric changes in fMRI connectivity networks in schizophrenia patients

Mohammad R. Arbabshirani; Marios S. Pattichis; Alvaro Ulloa; Vince D. Calhoun

doi:10.1109/EMBC.2014.6943693

Detecting volumetric changes in fMRI connectivity networks in schizophrenia patients

Mohammad R. Arbabshirani, Marios S. Pattichis, Alvaro Ulloa, Vince D. Calhoun

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

There is a growing interest in identifying neuroimaging-based biomarkers for schizophrenia. Previous studies have shown both functional and structural brain abnormalities in schizophrenia patients. One main category of these findings consists of volumetric abnormalities in brain structure in different cortical and subcortical structures in patients' brain. However there has been little work investigating changes in the brain's functional volumes. Nor has there been work studying differences in brain networks as opposed to single regions. In this study, we investigated the volumes of functional networks as potential biomarkers. Independent component analysis was used to decompose fMRI images into maximally independent spatial maps and corresponding time-courses. Volume of functional networks was computed from subject-specific back reconstructed spatial maps. The results show that different nodes of the default-mode network exhibit volumetric abnormalities in schizophrenia patients. Interestingly these networks are larger in patients compared to controls.

Original language	English (US)
Title of host publication	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	726-729
Number of pages	4
ISBN (Electronic)	9781424479290
DOIs	https://doi.org/10.1109/EMBC.2014.6943693
State	Published - Nov 2 2014
Event	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States Duration: Aug 26 2014 → Aug 30 2014

Publication series

Name	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Other

Other	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Country/Territory	United States
City	Chicago
Period	8/26/14 → 8/30/14

ASJC Scopus subject areas

Health Informatics
Computer Science Applications
Biomedical Engineering
General Medicine

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10.1109/EMBC.2014.6943693

Cite this

Arbabshirani, M. R., Pattichis, M. S., Ulloa, A., & Calhoun, V. D. (2014). Detecting volumetric changes in fMRI connectivity networks in schizophrenia patients. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 726-729). Article 6943693 (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6943693

Detecting volumetric changes in fMRI connectivity networks in schizophrenia patients. / Arbabshirani, Mohammad R.; Pattichis, Marios S.; Ulloa, Alvaro et al.
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 726-729 6943693 (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Arbabshirani, MR, Pattichis, MS, Ulloa, A & Calhoun, VD 2014, Detecting volumetric changes in fMRI connectivity networks in schizophrenia patients. in 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014., 6943693, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Institute of Electrical and Electronics Engineers Inc., pp. 726-729, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Chicago, United States, 8/26/14. https://doi.org/10.1109/EMBC.2014.6943693

Arbabshirani MR, Pattichis MS, Ulloa A, Calhoun VD. Detecting volumetric changes in fMRI connectivity networks in schizophrenia patients. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc. 2014. p. 726-729. 6943693. (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014). doi: 10.1109/EMBC.2014.6943693

Arbabshirani, Mohammad R. ; Pattichis, Marios S. ; Ulloa, Alvaro et al. / Detecting volumetric changes in fMRI connectivity networks in schizophrenia patients. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 726-729 (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014).

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Detecting volumetric changes in fMRI connectivity networks in schizophrenia patients

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