Detecting autonomic response to pain in Rett syndrome

Heather M. O’Leary, Peter B. Marschik, Omar S. Khwaja, Eugenia Ho, Katherine V. Barnes, Tessa W. Clarkson, Natalie M. Bruck, Walter E. Kaufmann

Research output: Contribution to journalArticle

Abstract

Objective: To quantify pain response in girls affected by Rett syndrome (RTT) using electrodermal activity (EDA), a measure of skin conductance, reflecting sympathetic activity known to be modulated by physical and environmental stress. Methods: EDA increase, heart rate (HR) increase and Face Legs Activity Cry Consolability (FLACC) values calculated during venipuncture (invasive) and vital signs collection (non-invasive) events were compared with values calculated during a prior baseline and a RTT clinical severity score (CSS). Results: EDA and HR increase were significantly higher than baseline during venipuncture only and not significantly correlated with FLACC or CSS. EDA increase was the most sensitive measure of pain response. Conclusions: These preliminary findings revealed that motor impairment might bias non-verbal pain scales, underscore the importance of using autonomic measures when assessing pain and warrant further investigation into the utility of using EDA to objectively quantify RTT pain response to inform future RTT pain management.

Original languageEnglish (US)
Pages (from-to)108-114
Number of pages7
JournalDevelopmental Neurorehabilitation
Volume20
Issue number2
DOIs
StatePublished - Feb 17 2017
Externally publishedYes

Fingerprint

Rett Syndrome
Pain
Phlebotomy
Leg
Heart Rate
Vital Signs
Pain Management
Skin

Keywords

  • Electrodermal activity
  • FLACC
  • heart rate
  • pain
  • Rett syndrome
  • skin conductance

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Rehabilitation
  • Developmental Neuroscience

Cite this

O’Leary, H. M., Marschik, P. B., Khwaja, O. S., Ho, E., Barnes, K. V., Clarkson, T. W., ... Kaufmann, W. E. (2017). Detecting autonomic response to pain in Rett syndrome. Developmental Neurorehabilitation, 20(2), 108-114. https://doi.org/10.3109/17518423.2015.1087437

Detecting autonomic response to pain in Rett syndrome. / O’Leary, Heather M.; Marschik, Peter B.; Khwaja, Omar S.; Ho, Eugenia; Barnes, Katherine V.; Clarkson, Tessa W.; Bruck, Natalie M.; Kaufmann, Walter E.

In: Developmental Neurorehabilitation, Vol. 20, No. 2, 17.02.2017, p. 108-114.

Research output: Contribution to journalArticle

O’Leary, HM, Marschik, PB, Khwaja, OS, Ho, E, Barnes, KV, Clarkson, TW, Bruck, NM & Kaufmann, WE 2017, 'Detecting autonomic response to pain in Rett syndrome', Developmental Neurorehabilitation, vol. 20, no. 2, pp. 108-114. https://doi.org/10.3109/17518423.2015.1087437
O’Leary HM, Marschik PB, Khwaja OS, Ho E, Barnes KV, Clarkson TW et al. Detecting autonomic response to pain in Rett syndrome. Developmental Neurorehabilitation. 2017 Feb 17;20(2):108-114. https://doi.org/10.3109/17518423.2015.1087437
O’Leary, Heather M. ; Marschik, Peter B. ; Khwaja, Omar S. ; Ho, Eugenia ; Barnes, Katherine V. ; Clarkson, Tessa W. ; Bruck, Natalie M. ; Kaufmann, Walter E. / Detecting autonomic response to pain in Rett syndrome. In: Developmental Neurorehabilitation. 2017 ; Vol. 20, No. 2. pp. 108-114.
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