TY - JOUR
T1 - Detecting a clinically meaningful change in tic severity in Tourette syndrome
T2 - A comparison of three methods
AU - Jeon, Sangchoon
AU - Walkup, John T.
AU - Woods, Douglas W.
AU - Peterson, Alan
AU - Piacentini, John
AU - Wilhelm, Sabine
AU - Katsovich, Lily
AU - McGuire, Joseph F.
AU - Dziura, James
AU - Scahill, Lawrence
PY - 2013/11
Y1 - 2013/11
N2 - Objective: To compare three statistical strategies for classifying positive treatment response based on a dimensional measure (Yale Global Tic Severity Scale [YGTSS]) and a categorical measure (Clinical Global Impression-Improvement [CGI-I] scale). Method: Subjects (N. = 232; 69.4% male; ages 9-69. years) with Tourette syndrome or chronic tic disorder participated in one of two 10-week, randomized controlled trials comparing behavioral treatment to supportive therapy. The YGTSS and CGI-I were rated by clinicians blind to treatment assignment. We examined the percent reduction in the YGTSS-Total Tic Score (TTS) against Much Improved or Very Much Improved on the CGI-I, computed a signal detection analysis (SDA) and built a mixture model to classify dimensional response based on the change in the YGTSS-TTS. Results: A 25% decrease on the YGTSS-TTS predicted positive response on the CGI-I during the trial. The SDA showed that a 25% reduction in the YGTSS-TTS provided optimal sensitivity (87%) and specificity (84%) for predicting positive response. Using a mixture model without consideration of the CGI-I, the dimensional response was defined by 23% (or greater) reduction on the YGTSS-TTS. The odds ratio (OR) of positive response (OR. = 5.68, 95% CI. = [2.99, 10.78]) on the CGI-I for behavioral intervention was greater than the dimensional response (OR. = 2.86, 95% CI. = [1.65, 4.99]). Conclusion: A 25% reduction on the YGTSS-TTS is highly predictive of positive response by all three analytic methods. For trained raters, however, tic severity alone does not drive the classification of positive response.Clinicaltrials.gov identifiers: NCT00218777; NCT00231985.
AB - Objective: To compare three statistical strategies for classifying positive treatment response based on a dimensional measure (Yale Global Tic Severity Scale [YGTSS]) and a categorical measure (Clinical Global Impression-Improvement [CGI-I] scale). Method: Subjects (N. = 232; 69.4% male; ages 9-69. years) with Tourette syndrome or chronic tic disorder participated in one of two 10-week, randomized controlled trials comparing behavioral treatment to supportive therapy. The YGTSS and CGI-I were rated by clinicians blind to treatment assignment. We examined the percent reduction in the YGTSS-Total Tic Score (TTS) against Much Improved or Very Much Improved on the CGI-I, computed a signal detection analysis (SDA) and built a mixture model to classify dimensional response based on the change in the YGTSS-TTS. Results: A 25% decrease on the YGTSS-TTS predicted positive response on the CGI-I during the trial. The SDA showed that a 25% reduction in the YGTSS-TTS provided optimal sensitivity (87%) and specificity (84%) for predicting positive response. Using a mixture model without consideration of the CGI-I, the dimensional response was defined by 23% (or greater) reduction on the YGTSS-TTS. The odds ratio (OR) of positive response (OR. = 5.68, 95% CI. = [2.99, 10.78]) on the CGI-I for behavioral intervention was greater than the dimensional response (OR. = 2.86, 95% CI. = [1.65, 4.99]). Conclusion: A 25% reduction on the YGTSS-TTS is highly predictive of positive response by all three analytic methods. For trained raters, however, tic severity alone does not drive the classification of positive response.Clinicaltrials.gov identifiers: NCT00218777; NCT00231985.
KW - Clinical Global Impression
KW - Cognitive behavioral intervention
KW - Mixture model
KW - Signal detection analysis
KW - Tourette syndrome
KW - Yale Global Tic Severity Scale
UR - http://www.scopus.com/inward/record.url?scp=84884937088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884937088&partnerID=8YFLogxK
U2 - 10.1016/j.cct.2013.08.012
DO - 10.1016/j.cct.2013.08.012
M3 - Article
C2 - 24001701
AN - SCOPUS:84884937088
SN - 1551-7144
VL - 36
SP - 414
EP - 420
JO - Contemporary Clinical Trials
JF - Contemporary Clinical Trials
IS - 2
ER -