Detectable tenofovir levels in breast-feeding infants of mothers exposed to topical tenofovir

Lisa M. Noguchi, Elizabeth T. Montgomery, Joseph R. Biggio, Craig W. Hendrix, Debra L. Bogen, Sharon L. Hillier, James Y. Dai, Jeanna M. Piper, Mark A. Marzinke, Charlene S. Dezzutti, S. Karen Isaacs, Jill L. Schwartz, D. Heather Watts, Richard H. Beigi

Research output: Contribution to journalArticle

Abstract

Lactation studies are necessary evaluations of medications for reproductive-age women. We evaluated pharmacokinetics (PK), pharmacodynamics, safety, and adherence profiles associated with 7 days of 1% tenofovir (TFV) vaginal gel use during lactation. Tenofovir levels (maternal/infant serum, milk) and anti-HIV activity (milk), adverse events (AEs), and adherence were measured for 17 HIV-1-seronegative breast-feeding mother-infant pairs. Tenofovir use was well-tolerated and detected at low levels in maternal serum, milk, and infant serum but demonstrated no anti-HIV activity in milk.

Original languageEnglish (US)
Pages (from-to)5616-5619
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume60
Issue number9
DOIs
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Noguchi, L. M., Montgomery, E. T., Biggio, J. R., Hendrix, C. W., Bogen, D. L., Hillier, S. L., Dai, J. Y., Piper, J. M., Marzinke, M. A., Dezzutti, C. S., Isaacs, S. K., Schwartz, J. L., Watts, D. H., & Beigi, R. H. (2016). Detectable tenofovir levels in breast-feeding infants of mothers exposed to topical tenofovir. Antimicrobial agents and chemotherapy, 60(9), 5616-5619. https://doi.org/10.1128/AAC.00645-16