Detectability and characterization limits of fluorescent objects in turbid media

Xingde Li, T. Durduran, B. Chance, A. G. Yodh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Analytic solutions modelling the propagation of fluorescence photons in heterogeneous turbid media are employed to generate `simulated experimental data' with realistic signal-to-noise and investigate the detectability of fluorescent objects in deep turbid media. Transmission measurements show that for a realistic fluorophore concentration and lifetime variation, the smallest detectable object is about 0.2 cm in radius assuming 1% amplitude and 0.5° phase random noise. Moreover, fluorescent diffuse photon density waves amplitude and phase data measured at the assumed conditions suggest, that for known object size, fluorophore concentration and lifetime within the object can be well characterized over a broad parameter space.

Original languageEnglish (US)
Title of host publicationConference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS
Editors Anon
PublisherIEEE
Pages40
Number of pages1
Volume11
StatePublished - 1997
Externally publishedYes
EventProceedings of the 1997 Conference on Lasers and Electro-Optics, CLEO - Baltimore, MD, USA
Duration: May 18 1997May 23 1997

Other

OtherProceedings of the 1997 Conference on Lasers and Electro-Optics, CLEO
CityBaltimore, MD, USA
Period5/18/975/23/97

Fingerprint

Fluorophores
Photons
Fluorescence

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering
  • Industrial and Manufacturing Engineering

Cite this

Li, X., Durduran, T., Chance, B., & Yodh, A. G. (1997). Detectability and characterization limits of fluorescent objects in turbid media. In Anon (Ed.), Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS (Vol. 11, pp. 40). IEEE.

Detectability and characterization limits of fluorescent objects in turbid media. / Li, Xingde; Durduran, T.; Chance, B.; Yodh, A. G.

Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS. ed. / Anon. Vol. 11 IEEE, 1997. p. 40.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Li, X, Durduran, T, Chance, B & Yodh, AG 1997, Detectability and characterization limits of fluorescent objects in turbid media. in Anon (ed.), Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS. vol. 11, IEEE, pp. 40, Proceedings of the 1997 Conference on Lasers and Electro-Optics, CLEO, Baltimore, MD, USA, 5/18/97.
Li X, Durduran T, Chance B, Yodh AG. Detectability and characterization limits of fluorescent objects in turbid media. In Anon, editor, Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS. Vol. 11. IEEE. 1997. p. 40
Li, Xingde ; Durduran, T. ; Chance, B. ; Yodh, A. G. / Detectability and characterization limits of fluorescent objects in turbid media. Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS. editor / Anon. Vol. 11 IEEE, 1997. pp. 40
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