Detectability and characterization limits of fluorescent objects in turbid media

X. D. Li, T. Durduran, B. Chance, A. G. Yodh

Research output: Contribution to journalConference article

Abstract

Analytic solutions modelling the propagation of fluorescence photons in heterogeneous turbid media are employed to generate `simulated experimental data' with realistic signal-to-noise and investigate the detectability of fluorescent objects in deep turbid media. Transmission measurements show that for a realistic fluorophore concentration and lifetime variation, the smallest detectable object is about 0.2 cm in radius assuming 1% amplitude and 0.5° phase random noise. Moreover, fluorescent diffuse photon density waves amplitude and phase data measured at the assumed conditions suggest, that for known object size, fluorophore concentration and lifetime within the object can be well characterized over a broad parameter space.

Original languageEnglish (US)
Number of pages1
JournalConference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS
Volume11
StatePublished - Jan 1 1997
Externally publishedYes
EventProceedings of the 1997 Conference on Lasers and Electro-Optics, CLEO - Baltimore, MD, USA
Duration: May 18 1997May 23 1997

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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