Abstract
Previously identified single nucleotide polymorphisms (SNPs) in genome wide association studies (GWAS) of cardiovascular disease (CVD) in participants of mostly European descent were tested for association with subclinical cardiovascular disease (sCVD), coronary artery calcium score (CAC) and carotid intima media thickness (CIMT) in the Multi-Ethnic Study of Atherosclerosis (MESA). The data in this data in brief article correspond to the article Common Genetic Variants and Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis [1]. This article includes the demographic information of the participants analyzed in the article as well as graphical displays and data tables of the association of the selected SNPs with CAC and of the meta-analysis across ethnicities of the association of CIMT-c (common carotid), CIMT-I (internal carotid), CAC-d (CAC as dichotomous variable with CAC>0) and CAC-c (CAC as continuous variable, the log of the raw CAC score plus one) and CVD. The data tables corresponding to the 9p21 fine mapping experiment as well as the power calculations referenced in the article are also included.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 229-242 |
| Number of pages | 14 |
| Journal | Data in Brief |
| Volume | 7 |
| DOIs | |
| State | Published - Jun 1 2016 |
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Keywords
- Carotid intima-media thickness (CIMT)
- Common genetic variant
- Coronary artery calcium (CAC)
- Single nucleotide polymorphism (SNP)
- Subclincal atherosclerosis
ASJC Scopus subject areas
- General
- Education
Cite this
Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis : The Multi-ethnic Study of Atherosclerosis. / Vargas, Jose D.; Manichaikul, Ani; Wang, Xin Qun; Rich, Stephen S.; Rotter, Jerome I.; Post, Wendy S; Polak, Joseph F.; Budoff, Matthew J.; Bluemke, David A.
In: Data in Brief, Vol. 7, 01.06.2016, p. 229-242.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis
T2 - The Multi-ethnic Study of Atherosclerosis
AU - Vargas, Jose D.
AU - Manichaikul, Ani
AU - Wang, Xin Qun
AU - Rich, Stephen S.
AU - Rotter, Jerome I.
AU - Post, Wendy S
AU - Polak, Joseph F.
AU - Budoff, Matthew J.
AU - Bluemke, David A.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Previously identified single nucleotide polymorphisms (SNPs) in genome wide association studies (GWAS) of cardiovascular disease (CVD) in participants of mostly European descent were tested for association with subclinical cardiovascular disease (sCVD), coronary artery calcium score (CAC) and carotid intima media thickness (CIMT) in the Multi-Ethnic Study of Atherosclerosis (MESA). The data in this data in brief article correspond to the article Common Genetic Variants and Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis [1]. This article includes the demographic information of the participants analyzed in the article as well as graphical displays and data tables of the association of the selected SNPs with CAC and of the meta-analysis across ethnicities of the association of CIMT-c (common carotid), CIMT-I (internal carotid), CAC-d (CAC as dichotomous variable with CAC>0) and CAC-c (CAC as continuous variable, the log of the raw CAC score plus one) and CVD. The data tables corresponding to the 9p21 fine mapping experiment as well as the power calculations referenced in the article are also included.
AB - Previously identified single nucleotide polymorphisms (SNPs) in genome wide association studies (GWAS) of cardiovascular disease (CVD) in participants of mostly European descent were tested for association with subclinical cardiovascular disease (sCVD), coronary artery calcium score (CAC) and carotid intima media thickness (CIMT) in the Multi-Ethnic Study of Atherosclerosis (MESA). The data in this data in brief article correspond to the article Common Genetic Variants and Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis [1]. This article includes the demographic information of the participants analyzed in the article as well as graphical displays and data tables of the association of the selected SNPs with CAC and of the meta-analysis across ethnicities of the association of CIMT-c (common carotid), CIMT-I (internal carotid), CAC-d (CAC as dichotomous variable with CAC>0) and CAC-c (CAC as continuous variable, the log of the raw CAC score plus one) and CVD. The data tables corresponding to the 9p21 fine mapping experiment as well as the power calculations referenced in the article are also included.
KW - Carotid intima-media thickness (CIMT)
KW - Common genetic variant
KW - Coronary artery calcium (CAC)
KW - Single nucleotide polymorphism (SNP)
KW - Subclincal atherosclerosis
UR - http://www.scopus.com/inward/record.url?scp=84958973975&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958973975&partnerID=8YFLogxK
U2 - 10.1016/j.dib.2016.01.048
DO - 10.1016/j.dib.2016.01.048
M3 - Article
VL - 7
SP - 229
EP - 242
JO - Data in Brief
JF - Data in Brief
SN - 2352-3409
ER -