Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis

Jose D. Vargas; Ani Manichaikul; Xin Qun Wang; Stephen S. Rich; Jerome I. Rotter; Wendy S. Post; Joseph F. Polak; Matthew J. Budoff; David A. Bluemke

doi:10.1016/j.dib.2016.01.048

Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis

Jose D. Vargas, Ani Manichaikul, Xin Qun Wang, Stephen S. Rich, Jerome I. Rotter, Wendy S. Post, Joseph F. Polak, Matthew J. Budoff, David A. Bluemke

School of Medicine

Research output: Contribution to journal › Article

Abstract

Previously identified single nucleotide polymorphisms (SNPs) in genome wide association studies (GWAS) of cardiovascular disease (CVD) in participants of mostly European descent were tested for association with subclinical cardiovascular disease (sCVD), coronary artery calcium score (CAC) and carotid intima media thickness (CIMT) in the Multi-Ethnic Study of Atherosclerosis (MESA). The data in this data in brief article correspond to the article Common Genetic Variants and Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis [1]. This article includes the demographic information of the participants analyzed in the article as well as graphical displays and data tables of the association of the selected SNPs with CAC and of the meta-analysis across ethnicities of the association of CIMT-c (common carotid), CIMT-I (internal carotid), CAC-d (CAC as dichotomous variable with CAC>0) and CAC-c (CAC as continuous variable, the log of the raw CAC score plus one) and CVD. The data tables corresponding to the 9p21 fine mapping experiment as well as the power calculations referenced in the article are also included.

Original language	English (US)
Pages (from-to)	229-242
Number of pages	14
Journal	Data in Brief
Volume	7
DOIs	https://doi.org/10.1016/j.dib.2016.01.048
State	Published - Jun 1 2016

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Keywords

Carotid intima-media thickness (CIMT)
Common genetic variant
Coronary artery calcium (CAC)
Single nucleotide polymorphism (SNP)
Subclincal atherosclerosis

ASJC Scopus subject areas

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Cite this

Vargas, J. D., Manichaikul, A., Wang, X. Q., Rich, S. S., Rotter, J. I., Post, W. S., Polak, J. F., Budoff, M. J., & Bluemke, D. A. (2016). Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis. Data in Brief, 7, 229-242. https://doi.org/10.1016/j.dib.2016.01.048

Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis : The Multi-ethnic Study of Atherosclerosis. / Vargas, Jose D.; Manichaikul, Ani; Wang, Xin Qun; Rich, Stephen S.; Rotter, Jerome I.; Post, Wendy S.; Polak, Joseph F.; Budoff, Matthew J.; Bluemke, David A.

In: Data in Brief, Vol. 7, 01.06.2016, p. 229-242.

Research output: Contribution to journal › Article

Vargas, Jose D. ; Manichaikul, Ani ; Wang, Xin Qun ; Rich, Stephen S. ; Rotter, Jerome I. ; Post, Wendy S. ; Polak, Joseph F. ; Budoff, Matthew J. ; Bluemke, David A. / Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis : The Multi-ethnic Study of Atherosclerosis. In: Data in Brief. 2016 ; Vol. 7. pp. 229-242.

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10.1016/j.dib.2016.01.048