Desmoplastic and Neurotropic Melanoma: Analysis of 33 Patients with Lymphatic Mapping and Sentinel Lymph Node Biopsy

Lyndon D. Su, Douglas R. Fullen, Lori Lowe, Timothy S Wang, Jennifer L. Schwartz, Vincent M. Cimmino, Vernon K. Sondak, Timothy M. Johnson

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Desmoplastic and neurotropic melanoma (DNMM) occasionally metastasizes to regional lymph nodes and extranodal sites. The value of sentinel lymph node biopsy (SLNB) has not been demonstrated clearly for patients with DNMM. The authors report on the utility of SLNB in the management of patients with DNMM. METHODS. The authors identified 33 patients with DNMM who were seen during a 5-year period in their institution who underwent lymphatic mapping and SLNB. Clinical and histopathologic data were reviewed. RESULTS. Thirty-three patients with DNMM underwent SLNB (mean Breslow depth, 4. 0 mm; median, 2.8 mm). There were 25 male patients and 8 female patients with a median age of 61 years (range, 31-86 years). Fifty-two percent of tumors presented in the head and neck region, and 24% were associated with lentigo maligna. Four of 33 patients (12%) without clinical evidence of metastatic disease who underwent SLNB had at least 1 positive sentinel lymph node. No additional positive lymph nodes were found in subsequent therapeutic regional lymphadenectomy in any of these four patients. CONCLUSIONS. SLNB detected subclinical metastases of DNMM to regional lymph nodes. SLNB at the time of resection can provide useful information to guide early treatment and, coupled with lymphadenectomy in positive patients, may limit tumor spread and prevent recurrence at the draining lymph node basin.

Original languageEnglish (US)
Pages (from-to)598-604
Number of pages7
JournalCancer
Volume100
Issue number3
DOIs
StatePublished - Feb 1 2004
Externally publishedYes

Fingerprint

Sentinel Lymph Node Biopsy
Melanoma
Lymph Nodes
Lymph Node Excision
Hutchinson's Melanotic Freckle
Neoplasms
Neck
Head
Neoplasm Metastasis
Recurrence

Keywords

  • Desmoplastic
  • Melanoma
  • Metastasis
  • Neurotropic
  • Sentinel lymph node biopsy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Su, L. D., Fullen, D. R., Lowe, L., Wang, T. S., Schwartz, J. L., Cimmino, V. M., ... Johnson, T. M. (2004). Desmoplastic and Neurotropic Melanoma: Analysis of 33 Patients with Lymphatic Mapping and Sentinel Lymph Node Biopsy. Cancer, 100(3), 598-604. https://doi.org/10.1002/cncr.11947

Desmoplastic and Neurotropic Melanoma : Analysis of 33 Patients with Lymphatic Mapping and Sentinel Lymph Node Biopsy. / Su, Lyndon D.; Fullen, Douglas R.; Lowe, Lori; Wang, Timothy S; Schwartz, Jennifer L.; Cimmino, Vincent M.; Sondak, Vernon K.; Johnson, Timothy M.

In: Cancer, Vol. 100, No. 3, 01.02.2004, p. 598-604.

Research output: Contribution to journalArticle

Su, LD, Fullen, DR, Lowe, L, Wang, TS, Schwartz, JL, Cimmino, VM, Sondak, VK & Johnson, TM 2004, 'Desmoplastic and Neurotropic Melanoma: Analysis of 33 Patients with Lymphatic Mapping and Sentinel Lymph Node Biopsy', Cancer, vol. 100, no. 3, pp. 598-604. https://doi.org/10.1002/cncr.11947
Su, Lyndon D. ; Fullen, Douglas R. ; Lowe, Lori ; Wang, Timothy S ; Schwartz, Jennifer L. ; Cimmino, Vincent M. ; Sondak, Vernon K. ; Johnson, Timothy M. / Desmoplastic and Neurotropic Melanoma : Analysis of 33 Patients with Lymphatic Mapping and Sentinel Lymph Node Biopsy. In: Cancer. 2004 ; Vol. 100, No. 3. pp. 598-604.
@article{055e7a77061c4a27afb06030e3c7acbe,
title = "Desmoplastic and Neurotropic Melanoma: Analysis of 33 Patients with Lymphatic Mapping and Sentinel Lymph Node Biopsy",
abstract = "BACKGROUND. Desmoplastic and neurotropic melanoma (DNMM) occasionally metastasizes to regional lymph nodes and extranodal sites. The value of sentinel lymph node biopsy (SLNB) has not been demonstrated clearly for patients with DNMM. The authors report on the utility of SLNB in the management of patients with DNMM. METHODS. The authors identified 33 patients with DNMM who were seen during a 5-year period in their institution who underwent lymphatic mapping and SLNB. Clinical and histopathologic data were reviewed. RESULTS. Thirty-three patients with DNMM underwent SLNB (mean Breslow depth, 4. 0 mm; median, 2.8 mm). There were 25 male patients and 8 female patients with a median age of 61 years (range, 31-86 years). Fifty-two percent of tumors presented in the head and neck region, and 24{\%} were associated with lentigo maligna. Four of 33 patients (12{\%}) without clinical evidence of metastatic disease who underwent SLNB had at least 1 positive sentinel lymph node. No additional positive lymph nodes were found in subsequent therapeutic regional lymphadenectomy in any of these four patients. CONCLUSIONS. SLNB detected subclinical metastases of DNMM to regional lymph nodes. SLNB at the time of resection can provide useful information to guide early treatment and, coupled with lymphadenectomy in positive patients, may limit tumor spread and prevent recurrence at the draining lymph node basin.",
keywords = "Desmoplastic, Melanoma, Metastasis, Neurotropic, Sentinel lymph node biopsy",
author = "Su, {Lyndon D.} and Fullen, {Douglas R.} and Lori Lowe and Wang, {Timothy S} and Schwartz, {Jennifer L.} and Cimmino, {Vincent M.} and Sondak, {Vernon K.} and Johnson, {Timothy M.}",
year = "2004",
month = "2",
day = "1",
doi = "10.1002/cncr.11947",
language = "English (US)",
volume = "100",
pages = "598--604",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Desmoplastic and Neurotropic Melanoma

T2 - Analysis of 33 Patients with Lymphatic Mapping and Sentinel Lymph Node Biopsy

AU - Su, Lyndon D.

AU - Fullen, Douglas R.

AU - Lowe, Lori

AU - Wang, Timothy S

AU - Schwartz, Jennifer L.

AU - Cimmino, Vincent M.

AU - Sondak, Vernon K.

AU - Johnson, Timothy M.

PY - 2004/2/1

Y1 - 2004/2/1

N2 - BACKGROUND. Desmoplastic and neurotropic melanoma (DNMM) occasionally metastasizes to regional lymph nodes and extranodal sites. The value of sentinel lymph node biopsy (SLNB) has not been demonstrated clearly for patients with DNMM. The authors report on the utility of SLNB in the management of patients with DNMM. METHODS. The authors identified 33 patients with DNMM who were seen during a 5-year period in their institution who underwent lymphatic mapping and SLNB. Clinical and histopathologic data were reviewed. RESULTS. Thirty-three patients with DNMM underwent SLNB (mean Breslow depth, 4. 0 mm; median, 2.8 mm). There were 25 male patients and 8 female patients with a median age of 61 years (range, 31-86 years). Fifty-two percent of tumors presented in the head and neck region, and 24% were associated with lentigo maligna. Four of 33 patients (12%) without clinical evidence of metastatic disease who underwent SLNB had at least 1 positive sentinel lymph node. No additional positive lymph nodes were found in subsequent therapeutic regional lymphadenectomy in any of these four patients. CONCLUSIONS. SLNB detected subclinical metastases of DNMM to regional lymph nodes. SLNB at the time of resection can provide useful information to guide early treatment and, coupled with lymphadenectomy in positive patients, may limit tumor spread and prevent recurrence at the draining lymph node basin.

AB - BACKGROUND. Desmoplastic and neurotropic melanoma (DNMM) occasionally metastasizes to regional lymph nodes and extranodal sites. The value of sentinel lymph node biopsy (SLNB) has not been demonstrated clearly for patients with DNMM. The authors report on the utility of SLNB in the management of patients with DNMM. METHODS. The authors identified 33 patients with DNMM who were seen during a 5-year period in their institution who underwent lymphatic mapping and SLNB. Clinical and histopathologic data were reviewed. RESULTS. Thirty-three patients with DNMM underwent SLNB (mean Breslow depth, 4. 0 mm; median, 2.8 mm). There were 25 male patients and 8 female patients with a median age of 61 years (range, 31-86 years). Fifty-two percent of tumors presented in the head and neck region, and 24% were associated with lentigo maligna. Four of 33 patients (12%) without clinical evidence of metastatic disease who underwent SLNB had at least 1 positive sentinel lymph node. No additional positive lymph nodes were found in subsequent therapeutic regional lymphadenectomy in any of these four patients. CONCLUSIONS. SLNB detected subclinical metastases of DNMM to regional lymph nodes. SLNB at the time of resection can provide useful information to guide early treatment and, coupled with lymphadenectomy in positive patients, may limit tumor spread and prevent recurrence at the draining lymph node basin.

KW - Desmoplastic

KW - Melanoma

KW - Metastasis

KW - Neurotropic

KW - Sentinel lymph node biopsy

UR - http://www.scopus.com/inward/record.url?scp=1642494639&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642494639&partnerID=8YFLogxK

U2 - 10.1002/cncr.11947

DO - 10.1002/cncr.11947

M3 - Article

C2 - 14745878

AN - SCOPUS:1642494639

VL - 100

SP - 598

EP - 604

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 3

ER -