Designing prospective cohort studies for assessing reproductive and developmental toxicity during sensitive windows of human reproduction and development-the LIFE Study

Germaine M Buck Louis, Enrique F. Schisterman, Anne M. Sweeney, Timothy C. Wilcosky, Robert E. Gore-Langton, Courtney D. Lynch, Dana Boyd Barr, Steven M. Schrader, Sungduk Kim, Zhen Chen, Rajeshwari Sundaram

Research output: Contribution to journalArticle

Abstract

Summary Buck Louis GM, Schisterman EF, Sweeney AM, Wilcosky TC, Gore-Langton RE, Lynch CD, Boyd Barr D, Schrader SM, Kim S, Chen Z, Sundaram R, on behalf of the LIFE Study. Designing prospective cohort studies for assessing reproductive and developmental toxicity during sensitive windows of human reproduction and development-the LIFE Study. Paediatric and Perinatal Epidemiology 2011; 25: 413-424. The relationship between the environment and human fecundity and fertility remains virtually unstudied from a couple-based perspective in which longitudinal exposure data and biospecimens are captured across sensitive windows. In response, we completed the LIFE Study with methodology that intended to empirically evaluate a priori purported methodological challenges: • implementation of population-based sampling frameworks suitable for recruiting couples planning pregnancy; • obtaining environmental data across sensitive windows of reproduction and development; • home-based biospecimen collection; and • development of a data management system for hierarchical exposome data. We used two sampling frameworks (i.e. fish/wildlife licence registry and a direct marketing database) for 16 targeted counties with presumed environmental exposures to persistent organochlorine chemicals to recruit 501 couples planning pregnancies for prospective longitudinal follow-up while trying to conceive and throughout pregnancy. Enrolment rates varied from

Original languageEnglish (US)
Pages (from-to)413-424
Number of pages12
JournalPaediatric and Perinatal Epidemiology
Volume25
Issue number5
DOIs
StatePublished - Sep 2011
Externally publishedYes

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Human Development
Reproduction
Cohort Studies
Prospective Studies
Pregnancy
Fertility
Environmental Exposure
Licensure
Marketing
Information Systems
Registries
Fishes
Epidemiology
Databases
Pediatrics
Population

Keywords

  • cohort
  • enrolment
  • environment
  • fecundity
  • fertility
  • LIFE Study
  • preconception
  • pregnancy
  • study design

ASJC Scopus subject areas

  • Epidemiology
  • Pediatrics, Perinatology, and Child Health

Cite this

Designing prospective cohort studies for assessing reproductive and developmental toxicity during sensitive windows of human reproduction and development-the LIFE Study. / Louis, Germaine M Buck; Schisterman, Enrique F.; Sweeney, Anne M.; Wilcosky, Timothy C.; Gore-Langton, Robert E.; Lynch, Courtney D.; Boyd Barr, Dana; Schrader, Steven M.; Kim, Sungduk; Chen, Zhen; Sundaram, Rajeshwari.

In: Paediatric and Perinatal Epidemiology, Vol. 25, No. 5, 09.2011, p. 413-424.

Research output: Contribution to journalArticle

Louis, GMB, Schisterman, EF, Sweeney, AM, Wilcosky, TC, Gore-Langton, RE, Lynch, CD, Boyd Barr, D, Schrader, SM, Kim, S, Chen, Z & Sundaram, R 2011, 'Designing prospective cohort studies for assessing reproductive and developmental toxicity during sensitive windows of human reproduction and development-the LIFE Study', Paediatric and Perinatal Epidemiology, vol. 25, no. 5, pp. 413-424. https://doi.org/10.1111/j.1365-3016.2011.01205.x
Louis, Germaine M Buck ; Schisterman, Enrique F. ; Sweeney, Anne M. ; Wilcosky, Timothy C. ; Gore-Langton, Robert E. ; Lynch, Courtney D. ; Boyd Barr, Dana ; Schrader, Steven M. ; Kim, Sungduk ; Chen, Zhen ; Sundaram, Rajeshwari. / Designing prospective cohort studies for assessing reproductive and developmental toxicity during sensitive windows of human reproduction and development-the LIFE Study. In: Paediatric and Perinatal Epidemiology. 2011 ; Vol. 25, No. 5. pp. 413-424.
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