Designing dendrimer and miktoarm polymer based multi-tasking nanocarriers for efficient medical therapy

Anjali Sharma, Ashok Kakkar

Research output: Contribution to journalReview article

Abstract

To address current complex health problems, there has been an increasing demand for smart nanocarriers that could perform multiple complimentary biological tasks with high efficacy. This has provoked the design of tailor made nanocarriers, and the scientific community has made tremendous effort in meeting daunting challenges associated with synthetically articulating multiple functions into a single scaffold. Branched and hyper-branched macromolecular architectures have offered opportunities in enabling carriers with capabilities including location, delivery, imaging etc. Development of simple and versatile synthetic methodologies for these nanomaterials has been the key in diversifying macromolecule based medical therapy and treatment. This review highlights the advancement from conventional "only one function" to multifunctional nanomedicine. It is achieved by synthetic elaboration of multivalent platforms in miktoarm polymers and dendrimers by physical encapsulation, covalent linking and combinations thereof.

Original languageEnglish (US)
Pages (from-to)16987-17015
Number of pages29
JournalMolecules
Volume20
Issue number9
DOIs
StatePublished - Sep 1 2015

Keywords

  • Dendrimers
  • Drug delivery
  • Miktoarm polymers
  • Multifunctional
  • Nanocarriers
  • Nanomedicine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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