@article{45df333d76054df89d2998361b16affd,
title = "Designing an individually tailored multilevel intervention to increase engagement in hiv and substance use treatment among people who inject drugs with hiv: Hptn 074",
abstract = "People who inject drugs (PWID) face barriers to engagement in antiretroviral treatment (ART) and medication-assisted treatment (MAT). We detail the design, rapid preparation and adaptation, and systematic implementation of a flexible, individually tailored intervention for PWID in multiple settings: Indonesia, Ukraine, and Vietnam. HPTN 074 integrated systems navigation and counseling to facilitate entry and adherence to ART and MAT. Site-level guidance on the intervention involved in-depth interviews (IDIs) among PWID and their supporters and site-specific document review. IDIs emphasized ART misinformation and importance of social support for adherence. The document review revealed differences in health care system barriers, requiring an intervention that was flexible and tailored enough to address key outcomes. Implementation included regular debriefs for iterative adaptations based on participants{\textquoteright} needs, including booster counseling sessions and subsidizing pre-ART testing. HPTN 074 provides a unique framework implementing a flexible and scalable intervention to improve ART and MAT outcomes among PWID across multiple settings.",
keywords = "ART, HIV, Injection drug use, Medication-assisted treatment, Substance use",
author = "Lancaster, {Kathryn E.} and Miller, {William C.} and Tetiana Kiriazova and Riza Sarasvita and Quynh Bui and Ha, {Tran Viet} and Kostyantyn Dumchev and Hepa Susami and Hamilton, {Erica L.} and Scott Rose and Hershow, {Rebecca B.} and Go, {Vivian F.} and David Metzger and Hoffman, {Irving F.} and Latkin, {Carl A.}",
note = "Funding Information: Kathryn E. Lancaster and William C. Miller, are affiliated with the College of Public Health, The Ohio State University, Columbus, Ohio. Tetiana Kiriazova and Kostyantyn Dumchev are affiliated with the Ukrainian Institute on Public Health Policy, Kyiv, Ukraine. Riza Sarasvita is affiliated with the National Narcotics Board, Jakarta, Indonesia. Quynh Bui and Tran Viet Ha are affiliated with UNC Project Vietnam, Hanoi, Vietnam. Tran Viet Ha, Rebecca B. Hershow, and Vivian F. Go are affiliated with the Department of Health Behavior, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina. Hepa Susami is affiliated with the Abhipraya Foundation and Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Erica L. Hamilton and Scott Rose are affiliated with the Science Facilitation Department, Durham, North Carolina. David Metzger is affiliated with the Perel-man School of Medicine, University of Pennsylvania and the Treatment Research Institute, Philadelphia, Pennsylvania. Irving F. Hoffman is affiliated with the Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill. Carl A. Latkin is affiliated with the Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland. This work was supported by the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Mental Health (NIMH), and the National Institute on Drug Abuse (NIDA) of the National Institutes of Health (NIH); award numbers UM1AI068619 [HPTN Leadership and Operations Center], UM1AI068617 [HPTN Statistical and Data Management Center], UM1AI068613 [HPTN Laboratory Center], and the University of North Carolina at Chapel Hill Center for AIDS Research (P30 AI50410). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. We would like to thank the members of the HPTN 074 study site teams for their hard work and dedication to this project. Also, we are grateful for the support from the outreach community workers from each of the three sites. We would like to thank the participants for their invaluable contributions to this research Address correspondence to Kathryn E. Lancaster, 334 Cunz Hall, 1841 Neil Ave., Columbus, OH 43210. E-mail: lancaster.111@osu.edu Publisher Copyright: {\textcopyright} 2019 The Guilford Press.",
year = "2019",
month = apr,
language = "English (US)",
volume = "31",
pages = "95--110",
journal = "AIDS Education and Prevention",
issn = "0899-9546",
publisher = "Guilford Publications",
number = "2",
}